Abstract
The aim of the study was to determine the prevalence of abnormal cytological findings, high risk (HR)-HPV genotypes and to identify factors associated with an abnormal cytological findings in a cohort of HIV-infected males. Retrospective observational study on HIV-infected male patients who performed screening in the absence of clinical symptoms. Cytological abnormalities were classified as atypical squamous cells of undetermined significance (ASC-US), low-grade(LSIL) or high high-grade squamous intraepithelial lesion (HSIL). Logistic regression models were used to identify predictors of having LSIL/HSIL. Among 875 pts, abnormal cytology findings were observed in 254 (29%, 95% CI: 26.1%-32.1%) subjects: 142 (16%) had LSIL and 49 (6%) HSIL. Overall, 581 (66%, 95%CI: 63.2%-69.5%) subjects had ≥1 HR-HPV type and 269 (31%) had ≥2 HR HPV types. Multivariate logistic regression showed that subjects with multiple HR-HPV genotypes (OR = 1.351, 95%CI: 1.005-2.111) and with HPV-16 type (OR = 2.032, 95%CI: 1.313-3.146) were more likely to have LSIL/HSIL in addition to a lower CD4+/CD8+ ratio, a previous diagnosis of syphilis and a positive viral load. In another multivariate model, the presence of multiple HPV types in subjects with HPV-1...Continue Reading
References
Oct 1, 1996·Hematology/oncology Clinics of North America·D W NorthfeltJ M Palefsky
Jul 4, 1998·Lancet·J J GoedertR J Biggar
Sep 5, 2006·Vaccine·Nubia MuñozLutz Gissmann
Nov 20, 2012·The Journal of Infectious Diseases·Vikrant V SahasrabuddheNicolas Wentzensen
Feb 14, 2013·International Journal of Cancer. Journal International Du Cancer·Cristina GonzálezUNKNOWN CoRIS-HPV Study Group
Jun 5, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yifei HuSten H Vermund
Aug 13, 2013·International Journal of Cancer. Journal International Du Cancer·J Michael BerryJoel M Palefsky
Aug 24, 2013·Journal of Clinical Microbiology·Montserrat TorresUNKNOWN CoRIS-HPV Study Group
Jan 31, 2014·Journal of Clinical Microbiology·C Estrade, R Sahli
Jun 8, 2014·BMJ : British Medical Journal·Jacqui Wise
Nov 12, 2014·AIDS·Michèle D ZeierJean B Nachega
Sep 15, 2015·PloS One·Naoyoshi NagataShinichi Oka
Sep 24, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna Rosa GarbugliaAdriana Ammassari
Oct 2, 2015·The Lancet. HIV·Cristina MussiniUNKNOWN Icona Foundation Study Group
Feb 3, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·W FuchsUNKNOWN Competence Network for HIV/AIDS
Feb 3, 2016·AIDS·Alice M SchofieldHenry C Kitchener
May 10, 2016·Diagnostic Microbiology and Infectious Disease·Ardashel LatsuzbaiaJoël Mossong
Aug 24, 2016·BMC Infectious Diseases·Etienne E MüllerDavid A Lewis
Mar 16, 2017·BMC Genomics·Jane Shen-GuntherTim H M Huang
Citations
Mar 19, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A TodorovaC Traidl-Hoffmann
Oct 28, 2019·PloS One·Carmen Hidalgo-TenorioJuan Pasquau
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Boris RevolloGuillem Sirera
May 30, 2019·BMC Public Health·Saverio Giuseppe ParisiGiorgio Palù
Jan 12, 2020·BMC Infectious Diseases·Rocío Méndez-MartínezAlejandro García-Carrancá
Jul 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mar MasiáFélix Gutiérrez
Feb 29, 2020·The Lancet. HIV·Helen KellyPhilippe Mayaud