Presence of multiple variants of Borrelia burgdorferi in the natural reservoir Peromyscus leucopus throughout a transmission season.

Vector Borne and Zoonotic Diseases
Katherine I Swanson, Douglas E Norris

Abstract

White-footed mice (Peromyscus leucopus) serve as the principal reservoir for Borrelia burgdorferi and have been shown to remain infected for life. Complex infections with multiple genetic variants of B. burgdorferi occur in mice through multiple exposures to infected ticks or through exposure to ticks infected with multiple variants of B. burgdorferi. Using a combination of cloning and single strand conformation polymorphism (SSCP), B. burgdorferi ospC variation was assessed in serial samples collected from individual P. leucopus during a single transmission season. In individuals with ospC variation, at least seven ospC variants were recognized at each time point. One to four of these variants predominated at each time point; however, the predominant variants seldom remained consistent in an individual mouse throughout the entire sampling period. These results confirmed that mice in southern Maryland were persistently infected with multiple variants of B. burgdorferi throughout the transmission season. However, the presence of multiple ospC variants and the fluctuations in the frequency of these variants indicates that either new ospC variants are regularly introduced to this mouse population and predominate while the existing...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M OritaT Sekiya
Feb 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·P H Duray, R C Johnson
Oct 23, 1997·International Journal of Systematic Bacteriology·N Marti RasG Baranton
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J E Purser, S J Norris
Nov 6, 2004·Applied and Environmental Microbiology·Markéta DerdákováDurland Fish

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Citations

Jan 7, 2016·Neural Computation·Yunlong FengJohan A K Suykens
Feb 19, 2016·Neural Computation·Yiming Ying, Ding-Xuan Zhou
Oct 9, 2014·Parasitology·Maarten J Voordouw
May 4, 2016·Neural Computation·Yunlong FengJohan A K Suykens
Jul 16, 2016·PLoS Pathogens·Katharine S WalterMaria A Diuk-Wasser
Aug 25, 2016·Neural Computation·Daniel MartíStefano Fusi
Jul 9, 2016·Neural Computation·Hanyuan HangJohan A K Suykens
Jan 18, 2017·Neural Computation·Yunwen Lei, Ding-Xuan Zhou
Nov 8, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Andrew L Ferguson
Nov 12, 2016·Applied and Environmental Microbiology·Jonas DurandMaarten J Voordouw

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