Presence of negative inotropic agents in canine plasma during positive end-expiratory pressure

Circulation Research
G A GrindlingerH B Hechtman


Application of positive end-expiratory pressure (PEEP) will reduce cardiac output (CO). Humoral mediation of this event by circulating negative inotropic agents was examined using a rat papillary muscle bioassay. Twenty-seven dogs were anesthetized with an iv pentobarbital infusion. Plasma was obtained before and after 30 minutes of PEEP. The plasma was oxygenated in a small (4.5-ml) papillary muscle chamber using a diffusion membrane. An average PO2 of 416 mm Hg was achieved. PEEP plasma reduced developed tension (Tpd) from 2.16 +/- 1.0 to 1.90 +/- 1.05 g (P less than 0.0001). A fall in Tpd was observed whether or not CO was maintained constant with fluid infusion. Resting tension was unchanged. The percent reduction in Tpd correlated with the fall in CO (r = 0.63, P less than 0.01) when fluid was not infused to maintain CO. Reapplication of control plasma restored Tpd. Barbiturate levels in anesthetized dogs rose from 17.3 to 19.4 microns/ml during PEEP (P less than 0.1). Addition of pentobarbital to normal plasma led to a slight decrease in Tpd only when the concentration exceeded 99 microns/ml. In three experiments on ex vivo perfused hearts, application of PEEP led to lowering of peak systolic pressure (PSP) within 5 minut...Continue Reading


Oct 1, 1977·The American Journal of Medicine·H O HeinemannU S Ryan
Feb 6, 1975·The New England Journal of Medicine·P M SuterM D Isenberg
Feb 1, 1978·Annals of Surgery·J MannyH B Hechtman
Nov 1, 1976·The American Journal of Medicine·H O Heinemann, J B Lee
Feb 1, 1975·Chest·S I SaidN Hara
Feb 1, 1970·Archives internationales de physiologie et de biochimie·J L Pannier, J Weyne
Apr 1, 1974·Acta Physiologica Scandinavica·K A EdmanE Nilsson
Dec 24, 1970·The New England Journal of Medicine·A KumarH Pontoppidan
Sep 1, 1966·Anesthesiology·B C MorganW G Guntheroth
Jun 1, 1970·The American Journal of Physiology·J V TybergE H SONNENBLICK
Mar 1, 1971·The British Journal of Surgery·E M BerryH Wyllie
Jul 8, 1971·The New England Journal of Medicine·E H SONNENBLICK
Dec 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·A L GimenoA S Bedners
Dec 1, 1964·The American Journal of Physiology·E H SONNENBLICK
Jan 1, 1948·The American Journal of Physiology·A COURNAND, H L MOTLEY


Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M KahleP Martin
Oct 1, 2008·Intensive Care Medicine·François Feihl, Alain F Broccard
Oct 1, 1985·British Journal of Diseases of the Chest·W J Kinnear, J M Shneerson
Jul 1, 1987·Prostaglandins, Leukotrienes, and Medicine·W Durante, F A Sunahara
Feb 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·B Sidenö, J Vaage
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·A Versprille
Aug 8, 1981·British Medical Journal
Jan 1, 1994·Intensive Care Medicine·J E BerglundJ Landelius
Jan 1, 1994·Upsala Journal of Medical Sciences·J E BerglundS Jakobson
Nov 1, 1985·The Annals of Thoracic Surgery·M E LoresB R Wilcox
Jul 1, 1982·The American Journal of Medicine·G A ZimmermanM Cengiz
Mar 8, 1986·British Medical Journal·M J Harrison
Jan 14, 1999·Journal of Applied Physiology·S S BlevinsD E Carlson

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