Presence of neural progenitors in spontaneous canine gliomas: A histopathological and immunohistochemical study of 20 cases

The Veterinary Journal
Francisco FernándezMartí Pumarola

Abstract

Gliomas are the most common primary brain tumours in humans and are associated with a poor prognosis. An accurate animal model of human glioma tumorigenesis is needed to test new treatment strategies. Dogs represent a promising model because they develop spontaneous diffusely-infiltrating gliomas. This study investigated whether spontaneous canine gliomas contain cancer stem cells previously identified in all grades of human gliomas. Twenty spontaneous cases of canine gliomas were graded according to the human WHO classification. The expression of different markers of lineage differentiation was evaluated with immunohistochemistry as follows: nestin and CD133 for neural stem cells, doublecortin for neuronal progenitor cells, Olig2 for glial progenitor cells, glial fibrillary acidic protein, vimentin and S-100 for mature glial cells, and NeuN and βIII-tubulin for mature neurons. Gliomas were characterised as follows: five grade II (oligodendrogliomas); nine grade III (seven anaplastic oligodendrogliomas, one anaplastic astrocytoma, one anaplastic oligoastrocytoma); six grade IV (glioblastomas). Immunohistochemical evaluation revealed that (1) nestin and CD133 were expressed in all grades of gliomas with a higher proportion of po...Continue Reading

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Citations

Jan 26, 2016·Journal of Comparative Pathology·C HerranzM Pumarola
Sep 12, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Brittany McHaleDaniel R Rissi
Nov 23, 2017·The Journal of Veterinary Medical Science·Shota KawakamiToshinori Omi
Jun 2, 2018·Veterinary Pathology·Takuya E KishimotoHiroyuki Nakayama
Feb 16, 2021·Frontiers in Oncology·Ricardo Gómez-OlivaNoelia Geribaldi-Doldán
Jun 13, 2021·Journal of Veterinary Internal Medicine·Roberto José-LópezMartí Pumarola
Oct 12, 2021·Frontiers in Veterinary Science·Marcella MassiminiLeonardo Della Salda

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