PMID: 8938251Feb 9, 1996Paper

Presence of neuropeptide Y Y1 receptor mediating vasoconstriction in human cerebral arteries

Neuroscience Letters
T NilssonL Edvinsson

Abstract

The neuropeptide Y-induced vasoconstriction of human cerebral arteries is mediated by the neuropeptide Y Y1 receptor. We conclude this on the basis of our results from: (1) in vitro studies on neuropeptide Y agonists. Neuropeptide Y and pro34NPY caused potent and long-lasting contractions of human cerebral arteries, while NPY 13-36 had no contractile effect at all on the vessels tested; (2) in vitro studies using the selective Y1 receptor antagonist BIBP3226 which in increasing concentrations (10(-9)-10(-6)M) caused a parallel shift to the right of the neuropeptide Y concentration-response curve without change of the maximum contractile response (pA2 value 8.38 +/- 0.10); and (3) with reverse transcriptase-polymerase chain reaction (RT-PCR) we detected specific mRNA for a neuropeptide Y Y1 receptor in human pial and human middle cerebral arteries using three forward primers and one reverse primer.

References

Jan 1, 1992·British Journal of Pharmacology·L GrundemarR Håkanson
Aug 21, 1990·European Journal of Pharmacology·M B DoughtyR E Tessel
Oct 1, 1984·British Journal of Pharmacology·L EdvinssonC Wahlestedt
Dec 27, 1994·European Journal of Pharmacology·K RudolfH N Doods
May 1, 1994·Trends in Pharmacological Sciences·L Grundemar, R Håkanson

❮ Previous
Next ❯

Citations

Mar 29, 2002·Annals of Neurology·Rajani ChoudhuriNancy E J Berman
Jul 29, 1998·Archives of Oral Biology·R UddmanL Edvinsson
Nov 28, 1996·European Journal of Pharmacology·A BergdahlL Edvinsson
Dec 16, 1998·European Journal of Pharmacology·A BergdahlL Edvinsson
Jul 4, 1998·Brain Research. Brain Research Reviews·T HökfeltJ H Walsh
Jul 21, 1999·Journal of the Autonomic Nervous System·J TajtiL Edvinsson
Mar 22, 2000·British Journal of Pharmacology·Y DumontR Quirion
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R AbounaderE Hamel
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·L BaoT Hökfelt
Oct 28, 2011·Clinical and Translational Science·Asma EjazLeena Pradhan
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J YouR M Bryan
Feb 12, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Jackerott, L I Larsson
Oct 20, 1999·The Annals of Otology, Rhinology, and Laryngology·R UddmanL Edvinnsson
Dec 31, 1997·The American Journal of Physiology·M J Newhouse, C E Hill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.