PMID: 9183744Jun 20, 1997Paper

Presence of novel N-CAM glycoforms in the rat olfactory system

Journal of Neurobiology
B DowsingBrian Key

Abstract

The functional activity of the neural cell adhesion molecule N-CAM can be modulated by posttranslational modifications such as glycosylation. For instance, the long polysialic acid side chains of N-CAM alter the adhesion properties of the protein backbone. In the present study, we identified two novel carbohydrates present on N-CAM, NOC-3 and NOC-4. Both carbohydrates were detected on N-CAM glycoforms expressed by subpopulations of primary sensory olfactory neurons in the rat olfactory system. Based on the expression of NOC-3 and NOC-4 and the olfactory marker protein (OMP), four independent subpopulations of primary sensory olfactory neurons were characterized. These neurons expressed: both NOC-3 and NOC-4 but not OMP; both NOC-4 and OMP but not NOC-3; NOC-3, NOC-4, and OMP together; and OMP alone. The NOC-3- and NOC-4-expressing neurons were widely dispersed in the olfactory neuroepithelium lining the nasal cavity. The axons of NOC-4 expressing neurons innervated all glomeruli in the olfactory bulb, whereas the NOC-3 expressing axons terminated in a discrete subset of glomeruli scattered throughout the whole olfactory bulb. We propose that both NOC-3 and NOC-4 are part of a chemical code of olfactory neurons which is used in ...Continue Reading

References

May 1, 1975·Developmental Biology·P C Letourneau
Dec 1, 1990·Brain Research. Developmental Brain Research·B Key, R A Akeson
Jan 1, 1990·The Journal of Cell Biology·G KadmonM Schachner
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Aug 29, 1986·Neuroscience Letters·B Key, P P Giorgi
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Aug 1, 1994·Journal of Neuroscience Research·A ChenR A Akeson
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Jan 1, 1993·The European Journal of Neuroscience·H HallB Schmitz

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Citations

Sep 12, 2000·The Journal of Comparative Neurology·D M Yilmazer-HankeH Distel
Mar 14, 2002·The Anatomical Record·James E Schwob
Jul 12, 2001·The Journal of Comparative Neurology·J A St John, B Key
Mar 4, 2006·Journal of Molecular Histology·Fatemeh ChehrehasaBrian Key
Nov 24, 1999·Brain Research. Developmental Brain Research·J A St John, B Key
May 6, 1998·Current Opinion in Neurobiology·C E Holt, W A Harris
Feb 4, 1999·Annals of the New York Academy of Sciences·B Key
Jan 25, 2002·The Journal of Comparative Neurology·Katarina T TisayBrian Key
Oct 24, 2003·The Journal of Comparative Neurology·Brian W LipscombCharles A Greer
Feb 21, 2004·Nature Reviews. Neuroscience·Ralf Kleene, Melitta Schachner
Jun 29, 2004·The Journal of Comparative Neurology·Melonie Joanne StoranBrian Key
Jul 6, 2004·The Journal of Comparative Neurology·Nicholas J GibsonLeslie P Tolbert
Sep 25, 2004·Journal of Neurobiology·Melonie J Storan, Brian Key
Jul 16, 2010·Geriatrics & Gerontology International·Yuji Sato, Tamao Endo

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