PMID: 3769451Jan 1, 1986Paper

Presence of O6-methylguanine acceptor protein in the tissues of different classes of vertebrates and invertebrates

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
A D WoodheadE H Cao

Abstract

We have measured the ability of extracts of tissues from several species of mammals, birds, reptiles, amphibia and fish to demethylate adducts of O6-methylguanine in exogenous DNA by transfer of the methyl group to an acceptor protein. Our study also encompassed tissues from a smaller number of invertebrates, from arthropods, molluscs and annelids. The vertebrate tissues used were liver, brain, spleen and kidney. In the case of the invertebrates we sampled liver, neural tissue, gonads, digestive tract and hepatopancreas. There was no consistent change in the amount of acceptor activity per unit of protein or DNA going from cold-blooded to warm-blooded vertebrates. Liver invariably had the highest amount; this finding was not unexpected since metabolic processes in the liver are high, and good cellular protective mechanism important. Inter-class comparisons within the vertebrates are highly speculative, and hindered by the fact that there is little information on carcinogenesis in animals other than rodents and humans. O6-methylguanine acceptor activity was found in all the invertebrate tissues tested. The amounts were variable, 0.003-0.0051 fmol/micrograms cellular DNA, but the values fell within the range of those found in the...Continue Reading

References

May 15, 1973·Experientia·R MontesanoP N Magee
Mar 1, 1983·Mutation Research·M NäslundA Kolman
Jan 1, 1982·Annual Review of Biochemistry·B Singer, J T Kuśmierek
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Apr 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R HodgsonM Balls

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Citations

Nov 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E GristC Carlson
Jan 1, 1987·Pharmacology & Therapeutics·A E Pegg, M E Dolan
Apr 11, 2013·Aquatic Toxicology·Aude KienzlerAlain Devaux
Dec 9, 2016·Conservation Physiology·Douglas C WoodhamsLouise A Rollins-Smith

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