Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer

Infectious Agents and Cancer
Shegan GaoXiaoshan Feng

Abstract

Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined the presence of P. gingivalis in esophageal mucosa, and the relationship between P. gingivalis infection and the diagnosis and prognosis of ESCC. The presence of P. gingivalis in the esophageal tissues from ESCC patients and normal controls was examined by immunohistochemistry using antibodies targeting whole bacteria and its unique secreted protease, the gingipain Kgp. qRT-PCR was used as a confirmatory approach to detect P. gingivalis 16S rDNA. Clinicopathologic characteristics were collected to analyze the relationship between P. gingivalis infection and development of ESCC. P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed. Moreover, statistic correlations showed P....Continue Reading

References

May 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·E De KosterM Deltenre
Jul 5, 2001·Breast Cancer Research and Treatment·K YazawaS Taniguchi
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L H DangB Vogelstein
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Mikko P Salaspuro
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhiheng PeiMartin J Blaser
Aug 7, 2004·Seminars in Oncology·Katherine D Crew, Alfred I Neugut
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alyson J LittmanThomas L Vaughan
Jan 7, 2006·International Journal of Cancer. Journal International Du Cancer·Giorgia RandiCarlo La Vecchia
Jan 27, 2006·World Journal of Gastroenterology : WJG·Zhiheng PeiMartin J Blaser
Nov 24, 2006·PLoS Pathogens·Michael C SchmidChristoph Dehio
Feb 19, 2008·Microbes and Infection·Masae KuboniwaOzlem Yilmaz
Aug 4, 2009·Journal of Gastroenterology and Hepatology·Michio HongoTomotaka Shoji
Feb 17, 2010·Current Gene Therapy·David MorrisseyMark Tangney
Aug 10, 2010·Cancer Letters·Sung Soo KimSteven F Moss
Oct 1, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Annemarie BoleijHarold Tjalsma
Dec 6, 2011·Carcinogenesis·Christian R SalazarYu Chen
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liying YangZhiheng Pei
Jul 12, 2013·Carcinogenesis·Dominique S Michaud
Nov 28, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Shegan GaoXiaoshan Feng
Dec 18, 2013·European Journal of Immunology·George Hajishengallis, Richard J Lamont
Mar 13, 2014·Trends in Microbiology·Huizhi WangDavid A Scott
Mar 29, 2014·PLoS Pathogens·Sarah E Whitmore, Richard J Lamont
Jun 14, 2014·Journal of Innate Immunity·Ana Carolina MorandiniRobson Coutinho-Silva

❮ Previous
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Citations

Oct 28, 2016·Annals of the New York Academy of Sciences·Vincenzo Di PilatoPaolo Bechi
Jan 4, 2017·Nature Reviews. Microbiology·Aurélie GagnaireJean-Pierre Gorvel
Mar 24, 2018·British Dental Journal·G JiaL Ai
Apr 5, 2018·Scandinavian Journal of Gastroenterology·Elisabeth Norder GrusellMogens Bove
Jul 6, 2018·Journal of Clinical Periodontology·Tingting ShiYehuan Sun
Apr 10, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Concetta PanebiancoValerio Pazienza
Sep 17, 2018·FEMS Microbiology Reviews·Marines du Teil EspinaJan Maarten van Dijl
Oct 13, 2019·Annals of Surgical Oncology·Susumu MiuraYoshihiro Kakeji
Nov 8, 2019·Journal of Clinical Periodontology·Yun ZhangYehuan Sun
Jan 31, 2020·Pharmacology Research & Perspectives·Shirin Arastu-KapurLeslie J Holsinger
Feb 25, 2020·Journal of Dental Research·Z R FitzsimondsR J Lamont
Apr 2, 2020·Oncology Reviews·Soussan IraniMohammadreza Badiei
Sep 16, 2016·Microbial Ecology·Andres Gomez, Karen E Nelson
Jul 9, 2020·Cancer Medicine·Jiwei SunLili Chen
Jul 13, 2017·Current Medical Research and Opinion·Omer DizdarEzel Berker
May 27, 2017·International Journal of Microbiology·E Escamilla-GarcíaM Márquez
Apr 27, 2019·World Journal of Clinical Cases·Ying Zhou, Guang-Hua Luo
Sep 14, 2019·Infectious Agents and Cancer·Xiao-Bo LiuQiang Tong
Dec 18, 2019·Scientific Reports·Dana M WalshMarina R S Walther-Antonio
Jun 5, 2018·Annals of Gastroenterological Surgery·Yoshifumi BabaHideo Baba
Jan 24, 2019·Journal of Oral Microbiology·Ingar Olsen, Özlem Yilmaz
Jun 2, 2020·Frontiers in Pharmacology·Brunilda AlushiAlexander Lauten
Jun 13, 2017·Frontiers in Cellular and Infection Microbiology·Anna M LasicaJan Potempa
Feb 8, 2019·Infectious Agents and Cancer·Bartosz MalinowskiMichał Wiciński
Dec 25, 2019·Current Oral Health Reports·Mei ChungDominique S Michaud
Jun 14, 2020·Annals of the Rheumatic Diseases·Madeleine JenningKarl Skriner
Jul 18, 2020·Frontiers in Cellular and Infection Microbiology·Donghang LiQing Geng
May 23, 2020·Clinical and Experimental Gastroenterology·Lina ElsalemOsama Aloudat
May 10, 2020·Periodontology 2000·Ngozi NwizuRobert J Genco
Mar 15, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Yusuke SatoYoshihiro Minamiya
Aug 15, 2020·Molecular Oral Microbiology·Hye-Kyung JunBong-Kyu Choi
Dec 14, 2016·Middle East Journal of Digestive Diseases·Mahin GholipourReza Malekzadeh

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Methods Mentioned

BETA
biopsies
light microscopy
biopsy
PCR

Software Mentioned

SPSS

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