Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma

Cancer Science
Mari KuboshimaTakenori Ochiai

Abstract

SEREX has been applied to esophageal SCC, and the TRIM21 gene was identified as a novel SEREX antigen of esophageal SCC. The presence of s-TRIM21-Abs was confirmed by Western blotting using bacterially expressed TRIM21 gene product and was evaluated for clinicopathological significance in patients with esophageal SCC. s-TRIM21-Abs were detected in 18 (20%) of 91 patients with esophageal SCC but not in 42 healthy donors. The presence of s-TRIM21-Abs was partly associated with tumor size (P = 0.063) and poor survival (P = 0.067). To measure serum antibody levels, ELISA using purified recombinant TRIM21 protein was developed. The levels of s-TRIM21-Abs were significantly higher in patients with esophageal SCC than in healthy donors (P = 0.013). s-TRIM21-Abs may be a useful tumor marker to diagnose and predict disease progression in patients with esophageal SCC.

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Citations

Oct 28, 2016·Oncogene·S ElabdC Blattner
Dec 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongfei ZhangJianying Zhang
Jun 14, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jie WangJoshua LaBaer
Apr 21, 2021·Immunopharmacology and Immunotoxicology·Mónica Vázquez-Del MercadoMinoru Satoh
Sep 21, 2021·Biomarkers in Medicine·Kangjia XiaoRenquan Lu

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