PMID: 8997511Dec 23, 1996Paper

Presence of somatostatin sst2 receptors in the developing rat auditory system

Brain Research. Developmental Brain Research
V S ThossD Hoyer

Abstract

A transient expression of somatostatin mRNA as well as of the peptide itself has been described in the developing mammalian auditory brainstem. However, little is known about the presence, and the spatial and temporal pattern of somatostatin (SRIF) receptor subtypes in this system. Therefore, we investigated the distribution of SRIF receptor binding sites labeled with the radioligands [125I]LTT-SRIF-28, [125I]Tyr3-octreotide, and [125I]CGP 23996 (in buffers containing either Mg2+ or Na+ ions) within the developing auditory brainstem of the rat. In addition, we performed in situ hybridization with a 35P-labeled oligoprobe, specific for somatostatin sst2 receptor mRNA. We observed a transient expression of SRIF receptors, labeled with [125I]LTT-SRIF-28, [125I]Try3-octreotide, and [125I]CGP 23996 (only in the presence of Mg2+ ions), in all principal auditory nuclei during neonatal development. In the adult rats, however, only the inferior colliculus displayed significant SRIF receptor binding. A very similar spatiotemporal labeling pattern was found for sst2 receptor mRNA. Our in situ hybridization data, together with those on ligand binding, suggest a predominantly transient expression of sst2 receptors in the auditory system. Si...Continue Reading

References

May 22, 1992·Brain Research. Developmental Brain Research·D H SanesJ Tyson
Jul 1, 1991·Brain Research. Molecular Brain Research·B BhattacharyaP K Sarkar
Feb 1, 1990·Brain Research. Molecular Brain Research·M SekitaniM Tohyama
Oct 15, 1985·The Journal of Comparative Neurology·G R UhlJ B Martin
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 25, 1981·Brain Research·K TakatsukiM Tohyama
Aug 28, 1995·Brain Research. Developmental Brain Research·T Taniwaki, J P Schwartz
Jan 1, 1993·Trends in Neurosciences·G I Bell, T Reisine
Mar 1, 1995·Trends in Pharmacological Sciences·D HoyerJ E Taylor
Oct 14, 1994·Brain Research. Developmental Brain Research·S Murakami, Y Arai
Nov 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·D HoyerC Bruns
Jul 15, 1994·Brain Research. Developmental Brain Research·D M FerrieroR O Messing
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·J PérezD Hoyer
Feb 8, 1993·The Journal of Comparative Neurology·K Kandler, E Friauf
May 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Feb 15, 1996·European Journal of Pharmacology·V S ThossD Hoyer

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