Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients

Journal of Medical Virology
Jorge CassebAlberto José da Silva Duarte

Abstract

Human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and -2) are retroviruses that share similar routes of transmission and some individuals may have a dual infection. These co-infected subjects may be at increased risk for tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM)-like. To study the prevalence of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) among co-infected HIV-1/HTLV-1 subjects. Since July 1997, our group has been following a cohort to study the interaction of HTLV with HIV and/or hepatitis C virus (HCV), as well as HTLV-1-only infected asymptomatic carriers or those already presenting with TSP/HAM. During these 9 years, 296 HTLV-1-infected individuals were identified from a total of 538 patients who were referred to our clinic at the Institute of Infectious Diseases "Emílio Ribas," in São Paulo, Brazil. All subjects were evaluated by two neurologists, blinded to the HTLV status. TSP/HAM diagnosis was based on Kagoshima diagnostic criteria. A total of 38 HIV-1/HTLV-1 co-infected subjects were identified in this cohort: Twenty-six had already been diagnosed with AIDS and 12 remained asymptomatic. Six of 38 co-infected subjects (1...Continue Reading

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Citations

Jul 19, 2012·PloS One·Felipe von GlehnLeonilda M B Santos
Nov 29, 2012·Neurologic Clinics·Megan B Richie, Amy A Pruitt
Feb 18, 2011·Neurología : publicación oficial de la Sociedad Española de Neurología·M P Gil VillarC Pérez Lázaro
Dec 10, 2016·Journal of Medical Virology·Arthur PaivaJorge Casseb
Dec 7, 2013·Current Opinion in Infectious Diseases·Divya Dhasmana, Graham P Taylor
Dec 18, 2019·Retrovirology·Brice JégadoRenaud Mahieux
May 9, 2021·Neurotoxicology·Marius BagumaJoëlle Nsimire Chabwine
Apr 13, 2021·The Journal of Infectious Diseases·Hiroo KatsuyaYorifumi Satou
Aug 7, 2020·Neuroimmunomodulation·L T Araújo JanahúAdriano Gomes-Silva

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