Presenilin-1 in neuroblastoma cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
C LindbladC J Fowler

Abstract

Presenilin-1 expression was investigated in Neuro-2a cells using the alphaPS1Loop antibody. The bulk of the immunoreactivity was found as the approximately 18kDa C-terminal fragment. Hydrogen peroxide treatment of the Neuro-2a cells for 24 hours resulted in a concentration-dependent cytotoxicity with a critical concentration of hydrogen peroxide of approximately 20 mum. Treatment of the cells for 24hr with 10, 20 or 30 mum hydrogen peroxide did not produce obvious effects upon presenilin-1 C-terminal fragment immunoreactivity. It is suggested that the loss of presenilin-1-mediated neuroprotection that has been proposed to occur in Alzheimer's disease is not secondary to hydrogen peroxide-mediated cell stress.

References

Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G CookR W Doms
Apr 1, 1997·Trends in Neurosciences·J Hardy
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·M SeegerS Gandy
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J WalterC Haass
Mar 1, 1997·Neurobiology of Aging·K BaumannM Staufenbiel

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