Presenilin-2 polymorphisms and risk of sporadic AD: evidence from a meta-analysis

Gene
Chunhai ChenZhengping Yu

Abstract

Association studies of presenilin-2 (PSEN2) polymorphisms and sporadic Alzheimer's disease (AD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of the two most extensively studied PSEN2 polymorphisms, rs8383 and 5'indel, with the risk of sporadic AD. We systematically reviewed relevant studies retrieved by Medline, Pubmed, Embase, AlzGene, and CNKI. Data were analyzed using the Stata (v11.0) software package. The fixed effects model or random-effects model were applied depending on between-study heterogeneity. Publication bias was evaluated using Egger's test and Begg's funnel plots. Overall, the meta-analysis included 6 case-control studies for each polymorphism with 2186 confirmed AD cases and 2507 healthy controls in total. Analysis suggested a significant association between SNP rs8383 polymorphism and AD risk with no evidence of between-study heterogeneity or publication bias. In contrast, we found no evidence for an association between the 5'indel polymorphism and AD risk. Further stratified analyses by apolipoprotein ε4 status or ethnicity also failed to reveal a statistically significant as...Continue Reading

References

Sep 5, 2002·American Journal of Medical Genetics·W Mathias Howell, Anthony J Brookes
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Aug 28, 2007·Brain Research·Miguel Rodríguez-ManotasJuan Cabezas-Herrera
Jan 30, 2010·Lipids in Health and Disease·Inga KuhlmannGerald Rimbach
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Oct 20, 2010·Neuron·Lars BertramRudolph E Tanzi

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