Abstract
Association studies of presenilin-2 (PSEN2) polymorphisms and sporadic Alzheimer's disease (AD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of the two most extensively studied PSEN2 polymorphisms, rs8383 and 5'indel, with the risk of sporadic AD. We systematically reviewed relevant studies retrieved by Medline, Pubmed, Embase, AlzGene, and CNKI. Data were analyzed using the Stata (v11.0) software package. The fixed effects model or random-effects model were applied depending on between-study heterogeneity. Publication bias was evaluated using Egger's test and Begg's funnel plots. Overall, the meta-analysis included 6 case-control studies for each polymorphism with 2186 confirmed AD cases and 2507 healthy controls in total. Analysis suggested a significant association between SNP rs8383 polymorphism and AD risk with no evidence of between-study heterogeneity or publication bias. In contrast, we found no evidence for an association between the 5'indel polymorphism and AD risk. Further stratified analyses by apolipoprotein ε4 status or ethnicity also failed to reveal a statistically significant as...Continue Reading
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Citations
Aug 2, 2013·Journal of Human Genetics·Han-Na KimHyung-Lae Kim
Mar 26, 2016·Meta Gene·Myung-Jin MunWon-Cheoul Jang
Mar 6, 2016·Neuroscience Letters·Myung-Jin MunWon-Cheoul Jang
Nov 1, 2013·Experimental Animals·Koichi Ito
Sep 15, 2018·Experimental and Therapeutic Medicine·Wei ChenShiwei Duan