Presensitization accelerates allograft arteriosclerosis

Transplantation
F KolbJ B Michel

Abstract

Transplant arteriosclerosis is the major factor influencing allograft survival after the first year posttransplantation. The host's immunologic response is one of the principal effectors responsible for the constitution of this vascular wall lesion, but the effector pathway and the factors influencing the immune injury are not clear. In a rat abdominal aortic allograft model, we used a skin priming method to study the influence of sensitization on the occurrence of vascular wall lesions. Primed rats developed transplant arteriosclerosis lesions involving medial decellularization and intimal proliferation before the 21st day, whereas naive animals had the same lesions at 2 months posttransplantation. A significant difference between primed and naive rats was found for medial thickness (48.00 +/- 2.85 microm versus 79.34 +/- 2.55 microm, P<0.001) and smooth muscle cell content (160 +/- 28 cell/mm versus 466 +/- 19 cell/mm, P<0.001) at 21 days posttransplantation, and intimal hyperplasia was seen in primed animals at that time, whereas it was not observed in naive rats until the 60th day. The immune profile in naive and primed animals was different. The immune cells infiltrating the arterial wall in naive rats, were principally ma...Continue Reading

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Citations

Feb 5, 2004·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kenneth W GrafUNKNOWN Department of Orthopaedic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
May 14, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J Richard Steadman, William G Rodkey
Jan 8, 2000·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·P DebeerJ Bellemans
Oct 11, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Gonzalo MoraFrancisco Forriol
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Mar 22, 2003·The Knee·Gabriela Peters, Carl Joachim Wirth
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Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Bassam AlkhatibDidier Plissonnier
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Mar 31, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Baptiste MichelAntonino Nicoletti

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