Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol

Applied Microbiology and Biotechnology
Zhi-Long Xiu, An-Ping Zeng


1,3-Propanediol and 2,3-butanediol are two promising chemicals which have a wide range of applications and can be biologically produced. The separation of these diols from fermentation broth makes more than 50% of the total costs in their microbial production. This review summarizes the present state of methods studied for the recovery and purification of biologically produced diols, with particular emphasis on 1,3-propoanediol. Previous studies on the separation of 1,3-propanediol primarily include evaporation, distillation, membrane filtration, pervaporation, ion exchange chromatography, liquid-liquid extraction, and reactive extraction. Main methods for the recovery of 2,3-butanediol include steam stripping, pervaporation, and solvent extraction. No single method has proved to be simple and efficient, and improvements are especially needed with regard to yield, purity, and energy consumption. Perspectives for an improved downstream processing of biologically produced diols, especially 1,3-propanediol are discussed based on our own experience and recent work. It is argued that separation technologies such as aqueous two-phase extraction with short chain alcohols, pervaporation, reverse osmosis, and in situ extractive or perva...Continue Reading


Aug 28, 1998·Applied Microbiology and Biotechnology·H BieblW D Deckwer
Oct 26, 1999·Applied Microbiology and Biotechnology·H BieblW D Deckwer
Feb 9, 2000·Biotechnology Progress·J J Malinowski
Mar 10, 2001·Applied Microbiology and Biotechnology·M J Syu
Oct 17, 2002·Applied Microbiology and Biotechnology·M HartlepA-P Zeng
Apr 17, 2003·Journal of Industrial Microbiology & Biotechnology·Badal C Saha
Oct 29, 2003·Current Opinion in Biotechnology·Charles E Nakamura, Gregory M Whited
May 29, 2007·Current Opinion in Biotechnology·Syed Shams Yazdani, Ramon Gonzalez
Jul 13, 2007·Applied Biochemistry and Biotechnology·B G Hermann, M Patel

❮ Previous
Next ❯


Oct 25, 2008·Applied Microbiology and Biotechnology·Cuiqing MaPing Xu
Jan 6, 2009·Applied Microbiology and Biotechnology·Li-Hui SunZhi-Long Xiu
Apr 28, 2009·Applied Microbiology and Biotechnology·Kaloyan Petrov, Penka Petrova
Nov 26, 2009·Applied Microbiology and Biotechnology·Ni-Ni GuoDe-Hua Liu
Apr 3, 2010·Applied Microbiology and Biotechnology·Kaloyan Petrov, Penka Petrova
Mar 2, 2011·Applied Microbiology and Biotechnology·Pinki AnandRuchi G Marwah
Oct 11, 2011·Applied Microbiology and Biotechnology·Ben RaoYaling Shen
Apr 10, 2010·Journal of Industrial Microbiology & Biotechnology·Yu-Tze HorngPo-Chi Soo
May 15, 2010·Journal of Industrial Microbiology & Biotechnology·Liaoyuan ZhangYaling Shen
Oct 20, 2009·Biotechnology Letters·Zong-Ming ZhengDe-Hua Liu
Jun 1, 2011·World Journal of Microbiology & Biotechnology·Yun-Zhen XuDe-Hua Liu
Jan 22, 2009·Applied Biochemistry and Biotechnology·Xiao-Jun JiShuang Li
Jun 21, 2011·Applied and Environmental Microbiology·Michael KöpkeSéan D Simpson
Nov 8, 2013·BioMed Research International·Daria Szymanowska-PowałowskaKatarzyna Leja
Dec 11, 2013·Applied Microbiology and Biotechnology·Flora TsvetanovaKaloyan Petrov
Jun 12, 2013·Bioprocess and Biosystems Engineering·Donna Dietz, An-Ping Zeng
Oct 23, 2013·Journal of Bioscience and Bioengineering·Sangjun JeonYong Keun Chang
Jul 2, 2014·Journal of Industrial Microbiology & Biotechnology·Liaoyuan ZhangYaling Shen
Jul 30, 2014·Biotechnology Advances·Wouter Van HeckeHeleen De Wever
Dec 11, 2014·Microbial Cell Factories·Yudong JiangMo Xian
Oct 12, 2015·Applied Microbiology and Biotechnology·Rafael R de Oliveira, Wayne L Nicholson
May 27, 2011·Current Opinion in Biotechnology·Patrick J Westfall, Timothy S Gardner
Jan 29, 2011·Biotechnology Advances·Xiao-Jun JiPing-Kai Ouyang
Jul 6, 2010·New Biotechnology·Anand HiremathVidhya Rangaswamy
May 16, 2009·Biotechnology Advances·E Celińska, W Grajek
Mar 5, 2016·Membranes·Christopher John DaveyDarrell Alec Patterson
Aug 5, 2015·Applied Microbiology and Biotechnology·Duyen Thi Ngoc HuynhYoung-Rok Kim
Apr 1, 2015·Rejuvenation Research·Benjamin P Best

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.