Jan 1, 1975

Present statues of lung transplantation (author's transl)

Annales de l'anesthésiologie française
M Noirclerc

Abstract

It is difficult to sum up the justifications for pulmonary transplantation in man as out of 34 cases carried out up to now only the patient DEROM, has survived 10 months. In fact, analysis shows that all of the other cases cannot be taken into consideration, as there were technical problems, or the receivers were nearly in the threws of death and this was the case of the patient SALVATOR. Two important problems remain to be resolved: First of all that of obtaining grafts in good condition. In fact the sole source of donors remains irreversible comas, and it is known that after 24 hours of artificial respiration the lung has undergone irreparable damage. It is therefore necessary to develop a reliable method for preservation. Present experimental results show that lungs preserved for 48 hours and regrafted into other animals are not only functional, in the immediate, but the scintigraphic scanning graphs after a month, are comparable with those in control animals. Studies of coagulation have demonstrated that pulmonary rejection is characterised before infiltration by mononuclear cells, by major coagulation disorders. In the treated animals, rejection crises are preceded a few days earlier by hypercoagulability and a fall in cir...Continue Reading

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Mentioned in this Paper

Dioxygen
Mononuclear Cells
Thrombophilia
Lung
Cell Respiration
Myopathy
Corticosteroids, topical for treatment of hemorrhoids and anal fissures
Lung Transplantation
Blood Coagulation Disorders
Adrenal Cortex Hormones

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