PMID: 8949755Jan 1, 1996Paper

Present status, trends and needs in fast neutron therapy

Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
André Wambersie, H G Menzel

Abstract

Fast neutrons were introduced in cancer therapy, in the 1970s, on the basis of radiobiological arguments. After 30 years, these arguments are still valid and have not been refuted by more recent experimental data. Although neutron therapy has been applied routinely for about 25 years, there is still no general agreement concerning its value and its place among the other radiation therapy techniques. In order to be able to draw objective conclusions from the available clinical results and mainly to compare the results from the different centres in a relevant way, a consensus has to be reached on several issues: 1) a protocol for dose measurement in a homogeneous phantom in reference conditions; 2) dose computation at the level of the target volume(s) and the normal tissues at risk; 3) method of dose specification for reporting; and 4) specification of radiation quality in neutron therapy and the related RBE problems. The International Commission on Radiation Units and Measurements (ICRU) has published recommendations on Clinical Neutron Dosimetry (ICRU Report 45, 1989) which are now universally applied. As far as dose specification for reporting is concerned, ICRU recommendations for photons (ICRU Report 50, 1993) can be extende...Continue Reading

References

Jan 1, 1990·Annales de chirurgie de la main et du membre supérieur : organe officiel des sociétés de chirurgie de la main = Annals of hand and upper limb surgery·R Tubiana
Apr 1, 1990·International Journal of Radiation Biology·H G MenzelA Wambersie
Mar 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B J MijnheerA Wambersie
Nov 1, 1988·The British Journal of Radiology·S HornseyD K Bewley

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Citations

Jul 3, 1998·Medical Physics·D J Brenner, M Zaider
Sep 29, 2005·British Journal of Cancer·W P LevinT F DeLaney

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