Present trends in vitamin E research

BioFactors
Francesco Galli, Angelo Azzi

Abstract

Nearly after one century of research and thousands of publications, the physiological function(s) of vitamin E remain unclear. Available evidence suggests a role in cell homeostasis that occurs through the modulation of specific signaling pathways and genes involved in proliferative, metabolic, inflammatory, and antioxidant pathways. Vitamin E presence in the human body is under close metabolic control so that only alpha-tocopherol and, to a lower extent, gamma-tocopherol are retained and delivered to tissues. Other vitamin E forms that are not retained in the body in significant amounts, exhibit responses in vitro that are different form those of alpha-tocopherol and may include tumor cell specific toxicity and apoptosis. These responses provide a therapeutic potential for these minor forms, either as such or metabolically modified, to produce bioactive metabolites. These cellular effects go beyond the properties of lipophilic antioxidant attributed to alpha-tocopherol particularly investigated for its alleged protective role in atherosclerosis or other oxidative stress conditions. Understanding signaling and gene expression effects of vitamin E could help assign a physiological role to this vitamin, which will be discussed in...Continue Reading

References

Oct 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·René GysinTheresa Visarius
Jan 23, 2003·Nutrition Journal·Rong GaoMin Qui
Apr 20, 2004·Journal of Cellular and Molecular Medicine·Adelina MunteanuA Azzi
Apr 28, 2004·Biochemical and Biophysical Research Communications·Adelina MunteanuAngelo Azzi
May 12, 2004·Current Medicinal Chemistry·Jean-Marc Zingg, Angelo Azzi
Nov 13, 2004·Annals of Internal Medicine·Edgar R MillerEliseo Guallar
Jan 5, 2005·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Francesco GalliArdesio Floridi
Feb 16, 2005·Current Opinion in Gastroenterology·Maret G Traber
Mar 9, 2005·Annals of the New York Academy of Sciences·Maret G TraberRobert L Hamilton
Mar 9, 2005·Annals of the New York Academy of Sciences·Kanatol Kontush, Svetlana Schekatolina
Mar 9, 2005·Annals of the New York Academy of Sciences·Yoshiro SaitoEtsuo Niki
Mar 9, 2005·Annals of the New York Academy of Sciences·Carmela ConteFrancesco Galli
Sep 6, 2005·Free Radical Biology & Medicine·Robert GianelloEsra Ogru
Sep 29, 2005·The Annals of Pharmacotherapy·David Q Pham, Roda Plakogiannis
Oct 18, 2005·The Annals of Pharmacotherapy·Lisa A Boothby, Paul L Doering
Nov 17, 2005·The Annals of Pharmacotherapy·David Q Pham, Roda Plakogiannis
Apr 4, 2006·Archives of Biochemistry and Biophysics·Yesim NegisJean-Marc Zingg
Aug 23, 2006·Journal of Neurochemistry·Savita KhannaChandan K Sen
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Feb 27, 2007·Molecular Aspects of Medicine·Jean-Marc Zingg
Feb 27, 2007·Molecular Aspects of Medicine·Attilio Rigotti
Mar 1, 2007·JAMA : the Journal of the American Medical Association·Goran BjelakovicChristian Gluud
Apr 19, 2007·Annual Review of Nutrition·Maret G Traber
May 17, 2007·Mini Reviews in Medicinal Chemistry·Jean-Marc Zingg
Jun 15, 2007·Free Radical Biology & Medicine·Maret G Traber, Jeffrey Atkinson
Jun 15, 2007·Free Radical Biology & Medicine·Angelo Azzi
Jun 22, 2007·Journal of Lipid Research·Kamran AnwarM Mahmood Hussain
Jul 14, 2007·Vitamins and Hormones·Chandan K SenSashwati Roy
Jul 14, 2007·Vitamins and Hormones·Francesco GalliFrank J Kelly
Jul 14, 2007·Vitamins and Hormones·Jean-Marc Zingg
Jul 14, 2007·Vitamins and Hormones·Kimberly KlineBob G Sanders
Jul 14, 2007·Vitamins and Hormones·Jing Ni, Shuyuan Yeh
Jul 21, 2007·Free Radical Biology & Medicine·Debbie J MustacichMaret G Traber

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Citations

Jan 6, 2011·Der Urologe. Ausg. A·M TrottmannA J Becker
Apr 21, 2011·Genes & Nutrition·Valentina ViolaFrancesco Galli
Feb 5, 2013·Occupational and Environmental Medicine·Adam ProkopowiczIzabela Szołtysek-Bołdys
Jul 26, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Demetrius AlbanesStephanie J Weinstein
Jul 13, 2013·BMC Genomics·Juan J Gutierrez-GonzalezDavid F Garvin
Oct 31, 2012·International Journal of Molecular Sciences·Irina O ZakharovaNatalia F Avrova
Apr 28, 2012·Nutrition Reviews·Barry Halliwell
Nov 28, 2013·Nutrition Reviews·Karen A WeikelAllen Taylor
Mar 8, 2016·Journal of Pharmaceutical and Biomedical Analysis·Pierangelo TorquatoFrancesco Galli
Apr 29, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·C ZerbinatiL Iuliano
Mar 2, 2011·Molecular Aspects of Medicine·Maria MarinoFlavia Franconi
Jan 1, 2010·Current Gerontology and Geriatrics Research·Makoto SuzukiBradley J Willcox
Dec 14, 2011·Molecular Microbiology·Eva-Maria PatzewitzSylke Müller
Jan 3, 2013·Acta Ophthalmologica·Alice L Yu, Ulrich Welge-Lussen
Apr 7, 2015·Free Radical Biology & Medicine·Mohamed LabaziPaul L McNeil
Jul 25, 2012·The Science of the Total Environment·Maria Stefania SpagnuoloLeopoldo Iannuzzi
Jan 10, 2012·Biochimica Et Biophysica Acta·Francesco GalliUNKNOWN Working Group on Inflammation in Cystic Fibrosis
Dec 3, 2014·Archives of Medical Research·Andrea E TóthMária A Deli
Jun 9, 2016·TheScientificWorldJournal·Elena García-NavarroLeonardo Velasco
Sep 2, 2016·BioFactors·Marta PiroddiFrancesco Galli
Nov 7, 2016·Free Radical Biology & Medicine·Francesco GalliNesrin Kartal Özer
Dec 17, 2016·International Journal of Molecular Sciences·Patrizia AmbroginiAndrea Minelli
Jan 25, 2017·International Journal of Molecular Sciences·Irina O ZakharovaNatalia F Avrova
Aug 2, 2018·Journal of Cellular Physiology·Marina Montagnani MarelliPatrizia Limonta
Aug 23, 2018·Journal of Veterinary Internal Medicine·Patrick C Barko, David A Williams
Mar 5, 2011·The Journal of Dairy Research·Maria Stefania SpagnuoloLeopoldo Iannuzzi
Dec 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Junbo HeQixin Zhong
Apr 25, 2019·European Journal of Nutrition·Constantina ConstantinouDimitrios Kanakis
Feb 13, 2021·Antioxidants·Carmen Griñan-LisonSergio Granados-Principal

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