Abstract
The updated Banff classification allows for the diagnosis of antibody-mediated rejection (AMR) in the absence of peritubular capillary C4d staining. Our objective was to quantify allograft loss risk in patients with consistently C4d-negative AMR (n = 51) compared with C4d-positive AMR patients (n = 156) and matched control subjects without AMR. All first-year posttransplant biopsy results from January 2004 through June 2014 were reviewed and correlated with the presence of donor-specific antibody (DSA). C4d-negative AMR patients were not different from C4d-positive AMR patients on any baseline characteristics, including immunologic risk factors (panel reactive antibody, prior transplant, HLA mismatch, donor type, DSA class, and anti-HLA/ABO-incompatibility). C4d-positive AMR patients were significantly more likely to have a clinical presentation (85.3% vs. 54.9%, p < 0.001), and those patients presented substantially earlier posttransplantation (median 14 [interquartile range 8-32] days vs. 46 [interquartile range 20-191], p < 0.001) and were three times more common (7.8% vs 2.5%). One- and 2-year post-AMR-defining biopsy graft survival in C4d-negative AMR patients was 93.4% and 90.2% versus 86.8% and 82.6% in C4d-positive AMR ...Continue Reading
References
Jun 1, 1993·Kidney International·H E FeuchtE Albert
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lorraine C RacusenKiril Trpkov
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Douglas E SchaubelRobert A Wolfe
Jul 10, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S M BagnascoR A Montgomery
Aug 12, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J E LockeM S Leffell
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Banu SisPhilip F Halloran
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Niamh KieranJolanta Kowalewska
Sep 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LoupyD Nochy
Mar 11, 2010·JAMA : the Journal of the American Medical Association·Dorry L SegevRobert A Montgomery
Jan 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LoupyC H Legendre
Jun 24, 2011·Kidney International·Seema Baid-AgrawalRobert B Colvin
Jul 29, 2011·The New England Journal of Medicine·Robert A MontgomeryDorry L Segev
Jan 15, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sufia Husain, Banu Sis
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasUNKNOWN Banff meeting report writing committee
Feb 13, 2014·JAMA : the Journal of the American Medical Association·Abimereki D MuzaaleDorry L Segev
Feb 14, 2014·Transplantation·Adnan SharifRobert A Montgomery
Jun 11, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B J OrandiD L Segev
Jan 1, 2014·International Journal for Ion Mobility Spectrometry : Official Publication of the International Society for Ion Mobility Spectrometry·Jessica L StaymatesGreg Gillen
Citations
Dec 6, 2016·Expert Review of Cardiovascular Therapy·Nicholas Furiasse, Jon A Kobashigawa
Dec 20, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Anissa MoktefiMarie Matignon
Oct 11, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P R AguilarR R Hachem
Jan 3, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A MontgomeryD L Segev
Jul 10, 2018·Nature Reviews. Nephrology·Robert A MontgomeryAndrea A Zachary
May 15, 2018·Transplantation·Jorge MalheiroAntónio Cabrita
Nov 1, 2018·American Journal of Physiology. Renal Physiology·Alice DoreilleHeloise Cardinal
Dec 20, 2017·Journal of the American Society of Nephrology : JASN·Denis VigliettiCarmen Lefaucheur
Apr 28, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Rubin Zhang
Jan 8, 2017·Journal of the American Society of Nephrology : JASN·Madhav C MenonPeter S Heeger
Jan 13, 2019·Histopathology·Carine NgoAurélie Cazes
Oct 20, 2018·Transplantation·Sandesh ParajuliDidier A Mandelbrot
Jan 3, 2020·Transplantation·Carrie A SchinstockPhilip J O'Connell
Mar 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stijn E VerledenDanny Jonigk
Jul 7, 2018·Journal of Immunology Research·Haiyan XuRenfang Xu
Jun 13, 2017·The Journal of Clinical Investigation·Nicole M Valenzuela, Elaine F Reed
Jan 28, 2017·Journal of Immunology Research·Supreet SethiStanley C Jordan
Aug 24, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Babak J OrandiDorry L Segev
May 28, 2020·Frontiers in Immunology·Rossana FranzinGiuseppe Castellano
Mar 25, 2019·Frontiers in Immunology·Valentin GoutaudierMoglie Le Quintrec
Jul 1, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Courtenay M HolscherDorry L Segev
Jan 21, 2017·Kidney International·Mark HaasStanley C Jordan
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Laura P Halverson, Ramsey R Hachem
Jun 5, 2021·Journal of Cutaneous Pathology·Neslihan AkdoganSerdar Nasir
Jun 25, 2021·Experimental Cell Research·Mi-Yeon YuSeung Hee Yang
Aug 4, 2021·Journal of Hepatology·Brian T LeeThomas D Schiano