Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran

American Journal of Hematology
G ToogehF Peyvandi

Abstract

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disease characterized by prolonged bleeding time with normal platelet count and morphology. It is caused by the quantitative or qualitative deficiency of the platelet glycoprotein IIb-IIIa. In 382 Iranian patients with GT diagnosed at a single center during the period 1969-2001, consanguinity between parents was 86.6%, in accord with the high frequency of intrafamilial marriages in Iran. Almost all patients had had abnormal mucocutaneous bleeding (epistaxis and gum bleeding); at follow-up, 4/5 of the patients had been transfused at least once to control hemorrhagic episodes. As expected, almost all the patients had a normal platelet count while the leukocyte count was increased in 19.3%. Among women, an unexpected low rate of pregnancies was observed.

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P J NewmanB S Coller
Jan 23, 1999·The Journal of Clinical Investigation·K M Hodivala-DilkeR O Hynes
Aug 13, 2003·Journal of Thrombosis and Haemostasis : JTH·M LakP M Mannucci

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Citations

May 26, 2006·Orphanet Journal of Rare Diseases·Alan T Nurden
Jun 2, 2007·Journal of Periodontology·Hilal Uslu Toygar, Esra Guzeldemir
Mar 13, 2016·Transfusion Medicine Reviews·Man-Chiu PoonRainer Zotz
Nov 6, 2014·American Journal of Hematology·Gudrun BragadottirPall T Onundarson
Sep 24, 2005·Clinical and Laboratory Haematology·A AfrasiabiP M Mannucci
Aug 2, 2006·Journal of Thrombosis and Haemostasis : JTH·E J R NelsonA Srivastava
Nov 26, 2010·The Laryngoscope·R Raul RosasJames Sidman
Jun 8, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·C DomschkeF Schuetz
Apr 5, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·S SiddiqA Mumford
Mar 30, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·C SantoroM G Mazzucconi
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·F PeyvandiM Menegatti
Sep 14, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M BorhanyT Shamsi
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S J IsraelsD Mezzano
May 9, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Günhal Kamburoğlu, Hayyam Kiratli
Dec 30, 2014·International Journal of Laboratory Hematology·A AlbanyanT Owaidah
Dec 7, 2011·American Journal of Preventive Medicine·Amy D ShapiroUNKNOWN European Network Rare Bleeding Disorders Database
Feb 16, 2016·Journal of Pediatric and Adolescent Gynecology·Madhvi RajpurkarMeera Chitlur
Nov 4, 2016·International Journal of Laboratory Hematology·M Kannan, R Saxena
May 13, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·S HussainN Zaidi
Oct 22, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Meganathan Kannan, Renu Saxena
Aug 15, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Qi WangMiao Jiang
Oct 17, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Chaker AlouiOlivier Garraud
Aug 28, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mehran KarimiShiva Nasirabady
Aug 2, 2011·Expert Review of Hematology·Kelly CoxWalter H A Kahr
Aug 6, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alireza FarsinejadMohammad Faranoush
Feb 1, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Marieke C PuntKarin P M van Galen
Jun 20, 2020·International Journal of Laboratory Hematology·Tooba AliShagufta Khaliq
Jul 1, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·F Y Huq, R A Kadir
Nov 14, 2012·Expert Review of Hematology·Alan T NurdenPaquita Nurden
Sep 14, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Shadi TabibianAkbar Dorgalaleh
Feb 23, 2019·Journal of Pediatric Hematology/oncology·Smitha KongalappaAnand Prakash
Feb 19, 2021·Hematology/oncology and Stem Cell Therapy·Asma AlharbiSulman Basit

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