Presentation, histopathologic findings, and clinical outcomes in 7 cases of melanoma in situ of the nail unit

Archives of Dermatology
Whitney A HighR Stan Taylor

Abstract

To report on the presentation, histopathologic findings, and clinical outcomes for a case series of MIS of the nail apparatus because melanoma in situ (MIS) of the nail unit has not been well characterized in the literature. A division of a tertiary academic center specializing in micrographic excision of cutaneous neoplasms. Surgical records were searched for cases of MIS of the nail unit for the period of January 1, 1997, to December 31, 2002. The patient demographics and disease presentation, treatment, and clinical course were reviewed. Seven cases of MIS of the nail unit in white patients were identified. Longitudinal melanonychia was present in all cases, but dyspigmentation of the proximal nail fold and onychodystrophy were uncommon. Histopathologic analysis revealed poorly circumscribed proliferations of single cells over nests with variable pagetoid spread. Atypia was variable. Mitotic activity was low. All cases were treated with micrographic surgery. Amputation was avoided in 3 cases and was limited to partial distal interphalangeal amputation in the remainder. Six cases did not recur locally after initial surgical intervention. With an average of 24 months of follow-up, all patients were free of disease. Longitudina...Continue Reading

Citations

Oct 14, 2010·The American Journal of Dermatopathology·Anne TheunisJosette André
Apr 9, 2008·The American Journal of Surgical Pathology·Bijal AminKlaus J Busam
Jul 16, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nathaniel J Jellinek, Jacob H Bauer
Jul 12, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Judith Domínguez-CheritPilar Luis-Montoya
Jan 23, 2016·Annales de dermatologie et de vénéréologie·I Moulonguet, S Goettmann-Bonvallot
Oct 2, 2013·Clinics in Dermatology·Josette AndréAnne Theunis
Oct 2, 2013·Clinics in Dermatology·Bertrand RichertJosette André
Feb 1, 2011·The Journal of Hand Surgery·Daniel E MartinRobert J Goitz
Nov 6, 2010·Seminars in Cutaneous Medicine and Surgery·Beth S Ruben
Jan 23, 2008·Journal of the American Academy of Dermatology·Adam M RotundaRichard G Bennett
Apr 18, 2007·Journal of the American Academy of Dermatology·Nathaniel Jellinek
Feb 27, 2007·Journal of the American Academy of Dermatology·Ralph Peter BraunLuc Thomas
Jan 6, 2009·The Journal of Dermatology·Sumihisa ImakadoKazutoshi Hamada
Oct 2, 2014·The Journal of Dermatology·Yasuhiro NakamuraAkifumi Yamamoto
May 31, 2014·International Journal of Dermatology·Masaki SawadaMasashi Akiyama
Mar 14, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·F NeczyporenkoB Richert
Dec 15, 2005·Advances in Dermatology·Nathaniel J Jellinek
Jun 5, 2013·Archives of Plastic Surgery·Min Ji YunSung Tack Kwon
Aug 19, 2017·Plastic and Reconstructive Surgery·Kyeong-Tae LeeGoo-Hyun Mun
May 1, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·M LambertiniE Dika
Jun 13, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·S GoettmannI Zaraa
May 11, 2011·Expert Review of Anticancer Therapy·Vincenzo De GiorgiDaniela Massi
Aug 3, 2011·Expert Review of Anticancer Therapy·Jeremy R EtzkornL Frank Glass
Jul 30, 2014·Plastic and Reconstructive Surgery·Abigail Maciolek CochranMichael W Neumeister
Dec 4, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S LieberherrS M Seyed Jafari
Dec 15, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Vitaly TerushkinJohn A Zitelli
Dec 19, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ana F DuarteEckart Haneke
Feb 6, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Máira de Magalhães Mariano AsturSérgio Henrique Hirata
Jan 20, 2021·Actas dermo-sifiliográficas·E Ríos-ViñuelaC Requena
Aug 17, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Andrew MatsumotoDivya Srivastava
Mar 23, 2021·Dermatologic Clinics·Junqian ZhangChristopher J Miller
Jun 1, 2021·Actas dermo-sifiliográficas·E Ríos-ViñuelaC Requena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
Sameera HusainA Bernard Ackerman
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Matthias MoehrleHelmut Breuninger
© 2021 Meta ULC. All rights reserved