PMID: 8962116Dec 10, 1996Paper

Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen

Proceedings of the National Academy of Sciences of the United States of America
M Guéguen, E O Long

Abstract

Class I and II molecules of the major histocompatibility complex present peptides to T cells. Class I molecules bind peptides that have been generated in the cytosol by proteasomes and delivered into the endoplasmic reticulum by the transporter associated with antigen presentation. In contrast, class II molecules are very efficient in the presentation of antigens that have been internalized and processed in endosomal/lysosomal compartments. In addition, class II molecules can present some cytosolic antigens by a TAP-independent pathway. To test whether this endogenous class II presentation pathway was linked to proteasome-mediated degradation of antigen in the cytosol, the N-end rule was utilized to produce two forms of the influenza virus matrix protein with different in vivo half-lives (10 min vs. 5 h) when expressed in human B cells. Whereas class I molecules presented both the short- and the long-lived matrix proteins, class II molecules presented exclusively the long-lived form of antigen. Thus, rapid degradation of matrix protein in the cytosol precluded its presentation by class II molecules. These data suggest that the turnover of long-lived cytosolic proteins, some of which is mediated by delivery into endosomal/ lysos...Continue Reading

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Citations

Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dorothee SchmidChristian Münz
Sep 22, 2001·International Journal for Parasitology·C G Lüder, F Seeber
Jan 23, 1998·Peptides·A Maffei, P E Harris
Jul 19, 2008·Cell Death and Differentiation·J D Lünemann, C Münz
Oct 26, 2005·Cell Death and Differentiation·D Schmid, C Münz
Feb 28, 2002·Annual Review of Immunology·Nilabh ShastriThomas Serwold
Nov 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuhuan LiHong-Ming Hu
Feb 13, 2010·Current Opinion in Immunology·Christian Münz
May 10, 2006·Cellular Microbiology·Christian Münz
Mar 8, 2011·The EMBO Journal·Lan HuangLaurence C Eisenlohr
Apr 19, 2015·Journal of Experimental & Clinical Cancer Research : CR·Mohanad AldarouishLi-Xin Wang
Feb 23, 2010·Immunity·Heung Kyu LeeAkiko Iwasaki
Feb 28, 2009·Current Opinion in Immunology·Jelena NedjicLudger Klein
Aug 1, 2007·Immunity·Dorothee Schmid, Christian Münz
Aug 1, 1997·Immunology and Cell Biology·A Suhrbier
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graham S TaylorAlan B Rickinson
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samudra K DissanayakeSuzanne Ostrand-Rosenberg
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan SuDavid W Scott
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P MukherjeeS Rath
Dec 14, 2004·Science·Casper PaludanChristian Münz

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