Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2

Vaccine
Bettina LanghansUlrich Spengler

Abstract

In vitro immunization with HCV lipopeptide aa 20-44 results in antigen-specific T cells. Here, we studied whether presentation of the lipopeptide by dendritic cells (DC) results in enhanced T cell functions. DC-immunized T cells showed significantly augmented proliferation and IFN-gamma secretion upon HCV-specific re-stimulation. This effect was related to significantly increased expression of TLR2 on DC-immunized CD4+ T cells and required TLR2 triggering during re-stimulation. In contrast, numbers of HLA-A2-pentamer-positive CD8+ T cells and granzyme B-secreting T cells remained unchanged. Thus, up-regulation of TLR2 during immunization with DC enhances functions of CD4+ T cells but not CD8+ T cells.

Citations

May 23, 2008·Journal of Leukocyte Biology·Angela Dolganiuc, Gyongyi Szabo
Dec 14, 2006·Clinics in Liver Disease·Gyongyi Szabo, Angela Dolganiuc
Jan 4, 2007·Clinical Science·Ulrich Spengler, Jacob Nattermann
Dec 6, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·L DoldB Langhans

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