Presenting comparative study PRO results to clinicians and researchers: beyond the eye of the beholder

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Michael D BrundagePRO Data Presentation Stakeholder Advisory Board (various names and locations)

Abstract

Patient-reported outcome (PRO) results from clinical trials can inform clinical care, but PRO interpretation is challenging. We evaluated the interpretation accuracy and perceived clarity of various strategies for displaying clinical trial PRO findings. We conducted an e-survey of oncology clinicians and PRO researchers (supplemented by one-on-one clinician interviews) that randomized respondents to view one of the three line-graph formats (average scores over time for two treatments on four domains): (1) higher scores consistently indicating "better" patient status; (2) higher scores indicating "more" of what was being measured (better for function, worse for symptoms); or (3) normed scores. Two formats displayed proportions changed (pie/bar charts). Multivariate modeling was used to analyze interpretation accuracy and clarity ratings. Two hundred and thirty-three clinicians and 248 researchers responded; ten clinicians were interviewed. Line graphs with "better" directionality were more likely to be interpreted accurately than "normed" line graphs (OR 1.55; 95% CI 1.01-2.38; p = 0.04). No significant differences were found between "better" and "more" formats. "Better" formatted graphs were also more likely to be rated "very c...Continue Reading

References

Aug 1, 1994·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J E TillJ R Young
Aug 18, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A BezjakK M Taylor
Nov 25, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Catherine AcquadroUNKNOWN PRO Harmonization Group
Nov 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah Watkins BrunerUNKNOWN National Cancer Institute
Dec 24, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Joanne Greenhalgh
Aug 4, 2009·Lancet·Claire F Snyder, Neil K Aaronson
Feb 11, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Maria-Jose SantanaDale C Lien
Apr 14, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Heather-Jane AuUNKNOWN NCIC CTG Quality of Life Committee
Feb 1, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Michael BrundageKimberley Foley
Nov 4, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claire F SnyderMaria Santana
Nov 30, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Julie RouetteMichael D Brundage
May 28, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Michael D BrundageUNKNOWN PRO Data Presentation Stakeholder Advisory Board
Nov 26, 2015·Patient Education and Counseling·Elissa T BantugUNKNOWN PRO Data Presentation Stakeholder Advisory Board
May 12, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Katherine C SmithUNKNOWN PRO Data Presentation Stakeholder Advisory Board

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Citations

Jan 27, 2019·BMJ : British Medical Journal·Melanie CalvertNiels Henrik Hjollund
Dec 12, 2018·Journal of the American Medical Informatics Association : JAMIA·Maichou LorSuzanne Bakken
Dec 1, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Elliott TolbertUNKNOWN PRO Data Presentation Stakeholder Advisory Board
Apr 26, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·L F van de WaterH W M van Laarhoven
Oct 12, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claire SnyderUNKNOWN PRO Data Presentation Delphi Panel
Feb 1, 2022·Clinical Trials : Journal of the Society for Clinical Trials·Claire SnyderUNKNOWN PROTEUS-Trials Consortium

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