Presepsin and prognostic nutritional index are predictors of septic acute kidney injury, renal replacement therapy initiation in sepsis patients, and prognosis in septic acute kidney injury patients: a pilot study.

BMC Nephrology
Yuichiro ShimoyamaToshiaki Minami

Abstract

Sepsis is the most common cause of acute kidney injury (AKI) among critically ill patients. This study aimed to determine whether presepsin is a predictor of septic acute kidney injury, renal replacement therapy initiation (RRTi) in sepsis patients, and prognosis in septic AKI patients. Presepsin values were measured immediately after ICU admission (baseline) and on Days 2, 3, and 5 after ICU admission. Glasgow Prognostic Score (GPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, Prognostic Index, and Prognostic Nutritional Index (PNI) were measured at baseline, and total scores ("inflammation-presepsin scores [iPS]") were calculated for category classification. Presepsin values, inflammation-based prognostic scores, and iPS were compared between patients with and without septic AKI or RRTi and between survivors and non-survivors. Receiver operating characteristic curve analyses identified the following variables as predictors of septic AKI and RRTi in sepsis patients: presepsin on Day 1 (AUC: 0.73) and Day 2 (AUC: 0.71) for septic AKI, and presepsin on Day 1 (AUC: 0.71), Day 2 (AUC: 0.9), and Day 5 (AUC: 0.96), Δpresepsin (Day 2 - Day 1) (AUC: 0.84), Δpresepsin (Day 5 - Day 1) (AUC: 0.93), and PNI (AUC: 0...Continue Reading

References

Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelRichard J Whitley
Jul 9, 2005·Critical Care Medicine·Thierry CalandraUNKNOWN International Sepsis Forum Definition of Infection in the ICU Consensus Conference
Jan 21, 2006·Critical Care Medicine·Jean-Louis VincentUNKNOWN Sepsis Occurrence in Acutely Ill Patients Investigators
May 16, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Mark JonesAlastair N Graham
Mar 14, 2008·Current Medicinal Chemistry·I Herzum, H Renz
Mar 25, 2009·American Journal of Obstetrics and Gynecology·Stephan PolterauerLukas Hefler
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Feb 24, 2011·Nature Reviews. Nephrology·Raghavan Murugan, John A Kellum
May 12, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tatsuyori ShozushimaShigeatsu Endo
Aug 16, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yoshikazu Okamura, Hiroyuki Yokoi
Jun 14, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigeatsu EndoYoshikazu Okamura
Feb 5, 2013·The Lancet Infectious Diseases·Christina WackerPeter Schlattmann
Oct 22, 2013·Critical Care : the Official Journal of the Critical Care Forum·Bo LiuChun-Sheng Li
Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Sep 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Michael BehnesUrsula Hoffmann
Jun 2, 2015·PloS One·Takanobu NagataShoichi Maruyama
Jul 15, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Camille Chenevier-GobeauxYann-Erick Claessens
Aug 25, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ricardo CarpioGeorg Hess
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Aug 5, 2016·Diagnostic Microbiology and Infectious Disease·Gaku TakahashiYoshihiro Inoue

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