Oct 1, 1989

Preservation-induced pancreatitis in an isolated perfused pancreas model in the dog

Transplant International : Official Journal of the European Society for Organ Transplantation
J WahlbergF O Belzer

Abstract

In order to investigate pancreatitis caused by cold ischemic damage to pancreatic grafts, an isolated, normothermic, ex vivo perfusion model was employed. Canine pancreases were subjected to 24 and 48 h of cold ischemia and then reperfused. The results showed that cold ischemia results in pancreatitis as measured by weight gain (tissue edema) and elevated leakage of amylase into the perfusate. The addition of allopurinol to the perfusion system did not prevent the signs of pancreatitis. From the results it can be concluded that the isolated, perfused pancreas model in the dog is useful for studying preservation-induced pancreatitis. The absence of any effect of allopurinol treatment suggests that oxygen-free radicals mediated by the xanthine oxidase system is of minor importance for the pathogenesis of postischemic pancreatitis.

Mentioned in this Paper

Ischemia
Pathogenic Aspects
Allopurinol
Pathogenesis
Cold Temperature
Extravasation
Pancreatitis
Benign Tumor of Pancreas
Free Radicals
Caplenal

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