Preservation of anthocyanins in solid lipid nanoparticles: Optimization of a microemulsion dilution method using the Placket-Burman and Box-Behnken designs

Food Chemistry
Raheleh RavanfarMahmoud Reza Moein

Abstract

Anthocyanins are the main polyphenol components from red cabbage (Brassica oleracea L. Var. Capitata f. Rubra) extracts that have inherent antioxidant activities. Anthocyanins are effectively stable in acidic gastric digestion conditions, with nearly 100% phenol content recovery. However, the total phenol content recovery after simulated pancreatic digestion was approximately 25%. To protect anthocyanins against harsh environmental conditions (e.g., pH and temperature), solid lipid nanoparticles were prepared by the dilution of water in oil (w/o) microemulsions containing anthocyanins in aqueous media. The formulations were characterized for particle size and encapsulation efficiency. The formulation parameters (e.g., volume of the internal aqueous phase, homogenization time and the percentages of total lipid, total surfactant or stabilizer) were optimized using the Placket-Burman and Box-Behnken experimental designs. Entrapment efficiency (89.2 ± 0.3%) was calculated when the mean particle size was 455 ± 2 nm. A scanning electron microscopy study revealed the spherical morphology of the particles.

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Citations

Dec 6, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Anil Kumar Sahu, Vishal Jain
Jan 27, 2017·Annual Review of Food Science and Technology·Rohollah SadeghiJozef L Kokini
Jun 9, 2018·Critical Reviews in Food Science and Nutrition·Elham Assadpour, Seid Mahdi Jafari
Feb 1, 2020·Expert Opinion on Therapeutic Patents·Rishi PaliwalMukesh Kumar Sahu
Oct 21, 2020·Antioxidants·Alexandra BorgesJoana Oliveira
Nov 21, 2020·International Journal of Molecular Sciences·Joana F HenriquesLeonor M Almeida
May 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marcela Tavares LuizDelia Rita Tapia-Blácido
Jul 28, 2021·Applied Biochemistry and Biotechnology·Susmita GhoshRunu Chakraborty
Jan 23, 2018·ACS Applied Materials & Interfaces·Raheleh RavanfarAlireza Abbaspourrad
Oct 4, 2019·ACS Applied Materials & Interfaces·Raheleh Ravanfar, Alireza Abbaspourrad
Nov 27, 2021·Journal of Microencapsulation·Priya PatelPranav Shah

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