Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes.

Functional & Integrative Genomics
Vadim B FedorovBrian M Barnes

Abstract

Physical inactivity reduces mechanical load on the skeleton, which leads to losses of bone mass and strength in non-hibernating mammalian species. Although bears are largely inactive during hibernation, they show no loss in bone mass and strength. To obtain insight into molecular mechanisms preventing disuse bone loss, we conducted a large-scale screen of transcriptional changes in trabecular bone comparing winter hibernating and summer non-hibernating black bears using a custom 12,800 probe cDNA microarray. A total of 241 genes were differentially expressed (P < 0.01 and fold change >1.4) in the ilium bone of bears between winter and summer. The Gene Ontology and Gene Set Enrichment Analysis showed an elevated proportion in hibernating bears of overexpressed genes in six functional sets of genes involved in anabolic processes of tissue morphogenesis and development including skeletal development, cartilage development, and bone biosynthesis. Apoptosis genes demonstrated a tendency for downregulation during hibernation. No coordinated directional changes were detected for genes involved in bone resorption, although some genes responsible for osteoclast formation and differentiation (Ostf1, Rab9a, and c-Fos) were significantly u...Continue Reading

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Citations

Dec 21, 2012·Kidney International·Peter StenvinkelRichard J Johnson
Oct 15, 2014·Molecular Ecology·Vadim B FedorovBrian M Barnes
Mar 27, 2015·International Journal of Endocrinology·Janina KueperJosh E Schroeder
Feb 5, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Øivind TøienBrian M Barnes
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Jan 11, 2018·Molecular Ecology·Sheena L FahertyAnne D Yoder
Sep 2, 2016·The Journal of Experimental Biology·Beau D Reilly, Craig E Franklin
Jan 31, 2020·Journal of Applied Physiology·Matthew D ReganC Loren Buck
Jan 4, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yasir ArfatCharles H Hocart
Dec 10, 2016·Psychopharmacology·Yury S TarahovskyNadezhda M Zakharova
Aug 28, 2020·PloS One·Alireza NasooriToshio Tsubota
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
Jan 16, 2021·Bone·Seth W DonahueHal L Black
Apr 17, 2021·Scientific Reports·Anna V GoropashnayaVadim B Fedorov

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