PMID: 2497410Jan 30, 1989Paper

Preservation of dopamine release in the denervated striatum

Neuroscience Letters
C A Altar, M R Marien

Abstract

Dopamine metabolism and release were determined in the striata of rats sustaining varying damage to the nigrostriatal dopamine (DA) projection. DA metabolism, inferred from concentrations of dihydroxy-phenylacetic acid (DOPAC) or homovanillic acid (HVA), decreased with DA denervation of more than 20%. Dopamine release, inferred from the concentration of 3-methoxytyramine (3-MT), did not decrease unless the denervation was at least 80%. The amount of 3-MT per surviving neuron exceeded that for DOPAC over most of the denervation range. Thus, striatal DA release is preserved at normal levels with the survival of only 20% of the striatal DA innervation. Decreases in DA release, rather than decreases in DA metabolism or the density of dopamine innervation, coincide with the appearance of behavioral impairments.

References

Nov 15, 1978·European Journal of Pharmacology·A M Di GiulioF Ponzio
Sep 1, 1976·Journal of Neurochemistry·C L GalliA Groppetti
May 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·U K RinneM Hyyppä
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Jul 2, 1984·Life Sciences·M J Zigmond, E M Stricker
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E MelamedR J Wurtman
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R E ZigmondC W Bowers
Oct 1, 1980·Journal of Comparative and Physiological Psychology·J F MarshallS Sawyer
Jan 1, 1985·Neurochemistry International·B H Westerink

❮ Previous
Next ❯

Citations

Nov 9, 2000·European Journal of Pharmacology·N JonkersY Michotte
Jan 4, 2001·Neurochemistry International·V Leviel
Nov 19, 2003·Journal of Neurochemistry·Sylvia MontañezAlan Frazer
Dec 1, 2004·The Journal of Nutrition·Fu-In Tang, Ien-Lan Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.