Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys

The Journal of Immunology : Official Journal of the American Association of Immunologists
Paula M AciernoN L Letvin

Abstract

Functional impairment of virus-specific memory CD8(+) T lymphocytes has been associated with clinical disease progression following HIV, SIV, and simian human immunodeficiency virus infection. These lymphocytes have a reduced capacity to produce antiviral cytokines and mediators involved in the lysis of virally infected cells. In the present study, we used polychromatic flow cytometry to assess the frequency and functional capacity of central memory (CD28(+)CD95(+)) and effector memory (CD28(-)CD95(+)) subpopulations of Gag-specific CD8(+) T cells in SIV/simian human immunodeficiency virus-infected rhesus monkeys. The aim of this study was to determine whether Ag-specific, memory CD8(+) T cell function could be preserved in infected monkeys that had been immunized before infection with a vaccine regimen consisting of a plasmid DNA prime followed by a recombinant viral vector boost. We observed that vaccination was associated with the preservation of Gag-specific central memory CD8(+) T cells that were functionally capable of producing IFN-gamma, and effector memory CD8(+) T cells that were capable of producing granzyme B following viral Ag exposure.

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Citations

Jul 31, 2008·AIDS Research and Human Retroviruses·Erik RollmanStephen J Kent
Aug 12, 2010·Journal of Medical Primatology·Tina SchultheissChristiane Stahl-Hennig
Mar 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lukas FlatzGary J Nabel
Dec 7, 2013·Expert Review of Vaccines·Larisa I KarpenkoIgor M Belyakov
Sep 14, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ali Azizi, Francisco Diaz-Mitoma
Mar 17, 2007·Clinical and Experimental Immunology·O NájeraR Ortiz
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali AziziFrancisco Diaz-Mitoma
Oct 6, 2007·Current Opinion in Rheumatology

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