PMID: 8944694Nov 1, 1996Paper

Preservation of intestinal gene expression during hibernation

The American Journal of Physiology
H V Carey, S L Martin

Abstract

The role of luminal nutrients in regulating enterocyte gene expression was studied in a natural model for long-term fasting, the hibernating ground squirrel. Squirrels were studied during the active season and during the hibernation season when they had not eaten for at least 12 wk. The specific activities of sucrase, isomaltase, and intestinal alkaline phosphatase in jejunal brush-border membranes were similar in hibernating and active squirrels, whereas amino-oligopeptidase was reduced in hibernators. Na(+)-K(+)-adenosinetriphosphatase activity in jejunal mucosa was unchanged by hibernation. Densitometric analysis of Western blots showed that abundance of sucrase-isomaltase (SI), amino-oligopeptidase, and the Na(+)-glucose cotransporter SGLT1 was similar in the two activity states. Preservation of SI abundance in hibernation was confirmed by immunocytochemistry. Slot-blot analysis revealed no differences in mRNA levels for these proteins between hibernating and active squirrels. Enterocyte proliferation and migration rates were greatly suppressed in torpid squirrels but increased immediately upon rewarming during arousals. These results demonstrate the striking constancy of enterocyte gene expression despite long-term fasting...Continue Reading

Citations

Jun 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Courtney C KurtzHannah V Carey
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keith B HengenStephen M Johnson
Nov 16, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hannah V CareyRob Knight
May 17, 2002·Journal of Applied Physiology·Frank Van Breukelen, Sandra L Martin
Aug 16, 2002·Physiological Genomics·L Elaine Epperson, Sandra L Martin
Oct 11, 2007·Physiological Genomics·Jun YanThomas G Marr
Nov 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K B HengenM Behan
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Courtney C Fleck, Hannah V Carey
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Apr 11, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew D ReganHannah V Carey
Apr 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sandra L MartinHannah V Carey
Dec 24, 2011·PloS One·Jessica P OtisHannah V Carey
Feb 9, 2021·Frontiers in Physiology·Sylvain GiroudKenneth B Storey
Apr 20, 2021·Frontiers in Physiology·Itamar B DiasRobert H Henning
Feb 26, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Andreas Balslev-ClausenHannah V Carey

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