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Preservation of methylated CpG dinucleotides in human CpG islands

Biology Direct

Mar 22, 2016

Alexander Y PanchinYulia A. Medvedeva

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Abstract

CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regi...read more

Mentioned in this Paper

Mutation Abnormality
Genome
thymidylyl-(3',5')-2'-deoxyguanosine
CpG Islands
Genome-Wide Association Study
Specimen Type - Fibroblasts
cytidylyl-3'-5'-guanosine
Methylate
Local
Malignant Neoplasm of Stomach
3
31
Paper Details
References

Preservation of methylated CpG dinucleotides in human CpG islands

Biology Direct

Mar 22, 2016

Alexander Y PanchinYulia A. Medvedeva

PMID: 27005429

DOI: 10.1186/s13062-016-0113-x

Abstract

CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regi...read more

Mentioned in this Paper

Mutation Abnormality
Genome
thymidylyl-(3',5')-2'-deoxyguanosine
CpG Islands
Genome-Wide Association Study
3
31
Paper Details
References

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