Preservation of shock-wave-induced renal histologic changes by dermatan sulfate

Urology
K SaricaO Gögüş

Abstract

To evaluate the protective effects of glycosaminoglycan (GAG) administration on shock-wave-induced renal histologic alterations, an experimental study using dermatan sulfate administration (DS) in rabbits was performed. The study included 45 white New Zealand rabbits; 36 were divided into two groups before shock-wave application. Animals in the first group (n = 18) received no specific medication before or after shock-wave treatment; animals in the second group (n = 18) received subcutaneous DS administration for a period of 2 months, beginning 2 weeks before shock-wave application. Following different numbers of shock-wave application (500, 1000, or 1500 shock waves), histopathologic evaluation of treated kidneys was made under light microscopy after 24 hours and 3 months. Nine animals were used for the control group. During 24-hour examination, most of the kidneys in both groups demonstrated varying degrees of histopathologic alterations, depending on the number of shock waves applied. Among the most prominent pathologic features were protein deposition with free erythrocytes in the tubular lumen, glomerular hemorrhage, tubular dilation and degeneration, protein in Bowman's capsule, hyperemia, and mononuclear cell infiltratio...Continue Reading

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Citations

Jul 14, 2004·Urological Research·Kemal SaricaRamazan Uçak
Oct 13, 2006·Current Opinion in Urology·D A Schulsinger, R E Sosa
Jun 23, 2009·The Journal of Urology·Yu-Quan XueXin-Yang Wang
Oct 9, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Youzhi ShaoJames E Lingeman

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