Preservation of vision following cell-based therapies in a model of retinal degenerative disease

Vision Research
Trevor J McGillGlen T Prusky

Abstract

This study examines whether subretinal transplantation of a human retinal pigment epithelial cell line (ARPE19) or human Schwann cells early in the course of degeneration can limit the loss of visual acuity that normally occurs in dystrophic Royal College of Surgeons (RCS) rats as they age. The acuity of both transplanted groups was significantly better than controls at all ages tested, though the rescue profile of each cell type was unique. These data indicate that the transplantation of cells with very different phenotypes can be used to limit the deterioration of spatial vision in an animal model of retinal degenerative disease.

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Citations

Oct 9, 2007·Progress in Retinal and Eye Research·Lyndon da CruzPete Coffey
Mar 28, 2007·American Journal of Ophthalmology·Marco A Zarbin
Sep 18, 2010·Pigment Cell & Melanoma Research·Kapil BhartiHeinz Arnheiter
Nov 20, 2013·Journal of Ophthalmology·Lara PasovicJon Roger Eidet
Aug 28, 2007·Vision Research·Frédéric Gaillard, Yves Sauvé
Aug 20, 2014·Ophthalmology and Therapy·Lara PasovicTor P Utheim
Apr 26, 2013·International Journal of Toxicology·William J BrockMaria I Rivera
Nov 4, 2017·Neurotoxicity Research·Amy E Lindsey, Ellen Townes-Anderson
Mar 24, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ann E CooperHenry Klassen
Apr 17, 2020·International Journal of Molecular Sciences·Céline KosterArthur A Bergen
Dec 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rakibul IslamTor Paaske Utheim

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