Preservative and Irritant Capacity of Biosurfactants From Different Sources: A Comparative Study

Journal of Pharmaceutical Sciences
L Rodríguez-LópezAna Belén Moldes

Abstract

One of the most important challenges for pharmaceutical and cosmetic industries is solubilization and preservation of their active ingredients. Therefore, most of these formulations contain irritant chemical additives to improve their shelf-life and the solubility of hydrophobic ingredients. An interesting alternative to chemical surfactants and preservatives is the use of biosurfactants; thus, their surfactant properties and composition make them more biocompatible than their chemical counterparts. Moreover, some biosurfactants have shown antimicrobial activity in addition to their detergent capacity. In this work, the antimicrobial and irritant effect of 2 biosurfactant extracts was studied: one produced in a controlled fermentation process with Lactobacillus pentosus and the other produced from corn stream by spontaneous fermentation. The results showed a strong antimicrobial activity of the biosurfactant extract obtained from corn stream on pathogenic bacteria, in comparison with the L. pentosus biosurfactant extract. Moreover, both biosurfactants did not produce any irritant effect on the chorioallantoic membrane of hen's egg assay contrary to sodium dodecyl sulfate. This is the first study dealing with the application of ...Continue Reading

Citations

Apr 17, 2020·The Journal of Dermatological Treatment·Lorena Rodríguez-LópezAna B Moldes
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana AlvesMadalena Pinto
Sep 27, 2020·International Journal of Molecular Sciences·Sib Sankar GiriSe Chang Park
Mar 7, 2021·International Journal of Molecular Sciences·Ana B MoldesJosé M Cruz
Dec 17, 2020·ACS Omega·Lorena Rodríguez-LópezAna B Moldes

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