Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Jerome AellenBernard Waeber

Abstract

Capillary rarefaction is a hallmark of untreated hypertension. Recent data indicate that rarefaction may be reversed by antihypertensive treatment in nondiabetic hypertensive patients. Despite the frequent association of diabetes with hypertension, nothing is known on the capillary density of treated diabetic patients with hypertension. We enrolled 21 normotensive healthy, 25 hypertensive only, and 21 diabetic (type 2) hypertensive subjects. All hypertensive patients were treated with a blocker of the renin-angiotensin system, and a majority had a home blood pressure ≤135/85 mmHg. Capillary density was assessed with videomicroscopy on dorsal finger skin and with laser Doppler imaging on forearm skin (maximal vasodilation elicited by local heating). There was no difference between any of the study groups in either dorsal finger skin capillary density (controls 101 ± 11 capillaries/mm(2) , nondiabetic hypertensive 99 ± 16, diabetic hypertensive 96 ± 18, p > 0.5) or maximal blood flow in forearm skin (controls 666 ± 114 perfusion units, nondiabetic hypertensive 612 ± 126, diabetic hypertensive 620 ± 103, p > 0.5). Irrespective of the presence or not of type 2 diabetes, capillary density is normal in hypertensive patients with reas...Continue Reading

References

Sep 1, 1979·Microvascular Research·B M FentonD M Worthen
Jul 18, 1978·Pflügers Archiv : European journal of physiology·H HenrichR Assmann
Jun 1, 1990·Hypertension·F Hansen-SmithJ H Lombard
Jul 1, 1982·Acta Physiologica Scandinavica·S LundinG Berglund
Sep 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·D W HaackJ G Simpson
Nov 1, 1995·Journal of the American Academy of Dermatology·R I KellyP S Mortimer
Feb 1, 1995·Journal of Hypertension·A PrasadG A MacGregor
Feb 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·A J JaapJ E Tooke
Mar 3, 1999·Clinical and Experimental Hypertension : CHE·P A van Zwieten
Apr 16, 1999·Hypertension·T F AntoniosG A MacGregor
May 26, 1999·American Journal of Hypertension·N KobayashiH Matsuoka
Aug 8, 2001·Circulation·B I LevyH A Struijker-Boudier
Aug 8, 2001·The Journal of Clinical Investigation·S DimmelerA M Zeiher
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·B C LeeJ E Tooke
Sep 25, 2001·Journal of Applied Physiology·C T MinsonM J Joyner
Jun 1, 2002·Circulation Research·Jean-Sébastien SilvestreBernard I Lévy
Dec 28, 2002·Diabetes Care·Carlos Arauz-PachecoUNKNOWN American Diabetes Association
Mar 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jefferson C Frisbee
May 6, 2003·Current Diabetes Reports·Elizabeth A Walker, Jennifer A Usher
Jun 5, 2003·Journal of Hypertension·UNKNOWN European Society of Hypertension-European Society of Cardiology Guidelines Committee
Dec 25, 2004·Diabetes Care·UNKNOWN American Diabetes Association
Jul 23, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobuhiko KobayashiGeert W Schmid-Schönbein
May 2, 2006·American Journal of Hypertension·Haythem DebbabiEduardo Tibiriçà
Jul 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Riikka KiveläVeikko Vihko
Oct 25, 2006·Hypertension·François FeihlBernard I Levy
Dec 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J MouradB I Levy
Apr 23, 2008·Hypertension·Dong YouJean-Sébastien Silvestre
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neeltje SteeghsEelco de Koning

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Citations

Dec 7, 2013·PloS One·Duncan J CampbellMary Jane Black
Dec 10, 2013·Cell and Tissue Research·Fabio Quondamatteo
Nov 5, 2016·The Journal of Clinical Hypertension·Agnes JumarRoland E Schmieder
Dec 10, 2016·PloS One·Agnes JumarRoland E Schmieder
Dec 23, 2017·BMC Cardiovascular Disorders·Agnes J BoschRoland E Schmieder
Mar 20, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jordan LoaderMatthieu Roustit
Jan 1, 2015·Vestnik oftalmologii·G Sh Arzhimatova, T S Hejlo

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