Preserved gastric tonometric variables in cardiac surgical patients administered intravenous perflubron emulsion

Anesthesia and Analgesia
Robert J FrumentoElliott Bennett-Guerrero

Abstract

Low gastric intramucosal pH (pHi) and an increased gastric-arterial PCO2 difference (CO2 gap) are markers of tissue hypoperfusion. Perfluorocarbons (PFCs) have a large oxygen-carrying capacity and release oxygen when encountering low tissue oxygen tension. Nine cardiac surgical patients instrumented for gastric tonometry were enrolled as part of a multicenter, randomized, single-blinded study of a PFC emulsion (perflubron emulsion [Oxygent]). Patients were randomized to receive PFC (n = 4) or placebo (n = 5) after intraoperative autologous blood harvesting by acute normovolemic hemodilution. At baseline there were no intergroup differences in tonometric-, hemodynamic-, or oxygen delivery-derived variables, e.g., Control group (pHi, 7.37 +/- 0.06; CO2 gap, 6.4 +/- 1.3 mm Hg) versus PFC group (pHi, 7.38 +/- 0.06; CO2 gap, 6.7 +/- 1.5 mm Hg). After acute normovolemic hemodilution, pHi was significantly lower (P < 0.01) in the Control group (7.22 +/- 0.25) than in the PFC group (7.44 +/- 0.25), and CO2 gap was significantly higher (P < 0.001) in the Control group (23.4 +/- 5.1 mm Hg) than in the PFC group (1.8 +/- 0.8 mm Hg). These differences in tonometric variables persisted during surgery. The PFC group showed a significantly (P...Continue Reading

References

Aug 1, 1991·Critical Care Medicine·G R DoglioG Gutierrez
Oct 1, 1994·Acta Anaesthesiologica Scandinavica·L Landow, L W Andersen
Feb 1, 1993·Critical Care Medicine·R G Fiddian-Green
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A T YilmazO Y Oztürk
Nov 1, 1996·Heart & Lung : the Journal of Critical Care·M J GrapG B Ball
Mar 31, 2000·British Journal of Anaesthesia·R G Fiddian-Green
May 25, 2001·Current Opinion in Critical Care·M A Hamilton, M G Mythen

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Citations

Jul 15, 2003·Tissue Engineering·Kenneth C Lowe
Jul 16, 2005·Der Anaesthesist·O HablerB Zwissler
Oct 6, 2006·Current Opinion in Anaesthesiology·Moheb Michael Mosa, Davy C H Cheng
Jul 5, 2006·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Raul C Verdin-VasquezJorge Barroso-Aranda
Aug 12, 2010·Artificial Organs·Camila Irene Castro, Juan Carlos Briceno
Jun 29, 2018·Chemistry : a European Journal·Yifeng PengBrian D Polizzotti
Apr 19, 2003·Journal of Internal Medicine·K C Lowe, E Ferguson
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Jun 1, 2005·Anesthesiology Clinics of North America·Caroline Thyes, Donat R Spahn

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