Preserved vasodilatory response to nitroglycerin in saphenous vein bypass grafts

Circulation
H BerglundR J Siegel

Abstract

Uncertainty exists regarding the effects of nitroglycerin on atherosclerotic segments of coronary arteries, and information on vasoreactivity of saphenous vein bypass grafts is sparse. Intravascular ultrasound enables identification of atherosclerosis in angiographically normal segments and allows continuous determination of alterations in cross-sectional lumen areas. Patients with documented coronary atherosclerosis were studied. Vessel morphology and lumen area at baseline and after 100 to 200 micrograms nitroglycerin were assessed at 10-second intervals for 60 seconds in vessel segments without angiographically apparent lesions. Coronary artery saphenous vein bypass grafts from 11 patients were compared with native coronary arteries in 16 different patients. Atherosclerosis was present in all vessel segments studied. There was a rapid increase in lumen area compared with baseline after intravascular nitroglycerin in both native coronary arteries and saphenous vein bypass grafts. Maximum lumen area dilatation was 19.6 +/- 12.2% in saphenous vein bypass grafts and 19.7 +/- 13.1% in native coronary arteries. An earlier peak response in saphenous vein bypass grafts (34.5 +/- 6.9 seconds) compared with native coronary arteries (4...Continue Reading

References

Mar 1, 1989·European Heart Journal·G D Angelini, A C Newby
Jun 1, 1988·Journal of the American College of Cardiology·G K JettR A Guyton
Oct 3, 1974·The American Journal of Cardiology·K K UnniA L Brown
Jan 1, 1995·Journal of the American College of Cardiology·M YamagishiA N DeMaria

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Citations

Aug 15, 2009·Journal of Vascular Surgery·Christopher D OwensJoshua A Beckman

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