Preserving vision in retinoblastoma through early detection and intervention.

Current Oncology Reports
S Epelman

Abstract

The most frequent neoplasm of the eye in children is retinoblastoma. It is a rare disease with an average incidence of 1 in 14,000 to 18,000 live births. The incidence is greater in developing countries. Early detection may allow widespread use of eye-sparing treatments, minimizing the morbidity of this disease. Although leukocoria is usually the first sign that parents notice especially when a flash photograph is taken, the diagnosis is not performed since this presentation is not known by health care providers and the public. Improving public awareness and knowledge of the early signs may lead to early diagnosis, which can save more eyes and lives. Advances in both the basic science and clinical applications of new therapies continue to emerge for this rare cancer. We expect that all conservative treatments will be available worldwide and consequently more children will be cured and maintain the vision.

References

Feb 1, 1990·Archives of Ophthalmology·J A ShieldsM E Giblin
Sep 1, 1989·Ophthalmic Paediatrics and Genetics·C M Erwenne, E L Franco
Sep 15, 1989·American Journal of Ophthalmology·J A ShieldsM E Giblin
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F DozL Desjardins
Oct 1, 1994·Human Genetics·D R LohmannB Horsthemke
May 1, 1993·Prenatal Diagnosis·J A Maat-KievitJ J van de Kamp
Jan 1, 1996·Experimental Gerontology·R S GuptaS Goldstein
Oct 1, 1996·British Medical Bulletin·C A Stiller, D M Parkin
Apr 17, 1998·The Journal of Pediatrics·D H AbramsonN W Boyd
Nov 27, 1999·The British Journal of Ophthalmology·A G GoddardJ L Hungerford
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L FriedmanA T Meadows
Sep 27, 2000·The British Journal of Ophthalmology·A C MollM Boers
Sep 10, 2002·Current Opinion in Ophthalmology·Patrick De Potter
Feb 13, 2003·Pediatric Clinics of North America·Samart Pakakasama, Gail E Tomlinson
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos Rodriguez-GalindoCharles B Pratt
Jan 15, 2004·Human Mutation·C HoudayerD Stoppa-Lyonnet
Jul 21, 2004·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Dietmar R Lohmann, Brenda L Gallie
Sep 15, 2004·American Journal of Ophthalmology·Carol L ShieldsJerry A Shields
Sep 15, 2004·American Journal of Ophthalmology·J William Harbour
Dec 8, 2004·Retina·Carol L ShieldsJerry A Shields
Mar 15, 2005·Ophthalmology Clinics of North America·R Max ConwayJoan M O'Brien
Sep 6, 2005·American Journal of Ophthalmology·Jerry A ShieldsAnna T Meadows
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikia A LaurieMichael A Dyer
Mar 22, 2006·Pediatric Blood & Cancer·Karina de Cássia Braga Ribeiro, Célia Beatriz Gianotti Antoneli
Sep 30, 2006·Pediatric Blood & Cancer·Christopher LeanderBarrett Haik
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Maura L GillisonBrenda L Gallie
Jun 21, 2007·Current Treatment Options in Neurology·Carlos Rodriguez-GalindoMatthew W Wilson
Oct 19, 2007·Pediatric Blood & Cancer·Brenda L GallieHelen S L Chan
Dec 22, 2007·Seminars in Ophthalmology·Yannek I LeidermanShizuo Mukai
Jan 29, 2008·Ophthalmology·Livia Lumbroso-Le RouicLaurence Desjardins
Feb 23, 2008·Clinical & Experimental Ophthalmology·Francis L MunierRaphaël Moeckli
Sep 3, 2008·Pediatrics·Carlos Rodriguez-GalindoJudith Wilimas
Oct 16, 2008·Current Opinion in Ophthalmology·Amy C Schefler, David H Abramson
Dec 11, 2008·Journal of the National Cancer Institute·Tamara MareesFlora E van Leeuwen
Jan 7, 2009·Journal of Pediatric Hematology/oncology·Adithi MohanSubramanian Krishnakumar
Mar 28, 2009·Pediatric Blood & Cancer·Judith A WilimasCarlos Rodriguez-Galindo
May 13, 2009·Pediatric Blood & Cancer·Guillermo L ChantadaDavid H Abramson
May 30, 2009·American Journal of Ophthalmology·Phoebe Lin, Joan M O'Brien

❮ Previous
Next ❯

Citations

Feb 26, 2013·The Lancet Oncology·Ian MagrathScott C Howard
Nov 4, 2016·Pediatric Blood & Cancer·Victoria W WillardSean Phipps
Jul 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria W WillardSean Phipps
Jul 19, 2016·Ophthalmic Genetics·Sameh E SolimanHelen Dimaras
Dec 23, 2017·Pediatric Blood & Cancer·Jennifer L HarmanVictoria W Willard
Apr 25, 2019·Pediatric Hematology and Oncology·Clarissa Campolina De Sá MattosinhoNathália Grigorovski
May 31, 2017·Asia-Pacific Journal of Ophthalmology·Nathalie CassouxLaurence Desjardins
Nov 17, 2020·Frontiers in Pediatrics·Jianbang ChiangJoanne Ngeow
Apr 2, 2021·Asia-Pacific Journal of Ophthalmology·Vijitha S Vempuluru, Swathi Kaliki
Apr 24, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria W WillardSean Phipps
May 1, 2021·International Journal of Clinical Practice·Abdallah Y NaserSalwan Salah Alwan
Jun 3, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Arunan SelvarajahHelen Dimaras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pediatric Hematology/oncology
Elliot NavoGuillermo L Chantada
Pediatric Blood & Cancer
Carlos Rodríguez-Galindo
International Journal of Cancer. Journal International Du Cancer
Rajaraman SwaminathanV Shanta
© 2022 Meta ULC. All rights reserved