Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats

Peptides
Quan FangRui Wang

Abstract

Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF(A) and pro-NPFF(B)) and two receptors (NPFF(1) and NPFF(2)). NPFF and NPFF receptor mRNAs have been reported to be highly expressed and localized in the rat and human spinal cord. In the present study, the i.t. action of NPFF system on blood pressure and heart rate were examined using NPFF and two related agonists, NPVF and dNPA, which exhibit highest selectivities for NPFF(1) and NPFF(2) receptors, respectively. In urethane-anesthetized rats, NPFF and related peptides (5-40 nmol, i.t.) produced significant pressor and tachycardic responses at the spinal cord level. These effects were dose-dependent and similar with respect to time-course for the three peptides. Furthermore, i.t. injection of RF9 (20 nmol), a selective NPFF antagonist, significantly antagonized the cardiovascular responses to 20 nmol NPFF and related peptides (i.t.). Moreover, pretreatment of the rats with alpha-adrenoceptor antagonist phentolamine (1mg/kg, i.v.) significantly reduced the pressor effects of NPFF. Nevertheless, pretreatment with muscarinic receptor and adrenoceptor antagonists (i.v.) could block the tachycardic effects induced by NPFF. Collectively, our re...Continue Reading

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Citations

Jul 6, 2014·Frontiers in Endocrinology·Maurice R Elphick, Olivier Mirabeau
Oct 28, 2015·Acta Neurologica Scandinavica·I BuffelP Boon
Jul 29, 2011·The Oncologist·Giuseppe LombardiVittorina Zagonel
Dec 2, 2020·International Journal of Molecular Sciences·Piotr WojciechowskiKatarzyna Kaczyńska
Jul 17, 2020·Journal of Medicinal Chemistry·Thuy NguyenYanan Zhang

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