PMID: 8950281Jan 1, 1996Paper

Pressor effect of the putative M1 muscarinic receptor agonist MCN-A-343 in the conscious rat

Life Sciences
J R Martin

Abstract

The putative M1 muscarinic receptor agonist McN-A-343 evoked a dose-dependent increase in mean arterial pressure (MAP) when administered intravenously to conscious freely-moving rats pretreated with the ganglionic nicotinic receptor antagonist pentolinium. A tachycardia accompanied the increase in MAP which was blocked by the beta-adrenergic receptor antagonist propranolol. The increase in MAP was attenuated by the alpha 1-adrenergic receptor antagonist prazosin combined with the alpha 2-adrenergic receptor antagonist yohimbine. Adding propranolol to alpha-adrenergic receptor blockade uncovered a latent pressor response. Replacing prazosin with benextramine (which blocks NPY in addition to alpha-adrenergic receptors) attenuated the pressor response unmasked by propranolol. This attenuation was comparable to that provided by benextramine of the pressor response to intravenous administration of NPY. Adrenal demedullation only slightly attenuated the pressor response while having no effect on the tachycardia. The catecholamine depletor guanethidine greatly attenuated the McN-A-343-evoked increase in MAP and heart rate. The combination of adrenal demedullation and guanethidine did not further attenuate the increase in MAP but did p...Continue Reading

References

Jan 1, 1992·Annual Review of Physiology·K M BakerD E Dostal
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·J M LundbergM Goldstein
Jan 1, 1988·Pharmacology & Therapeutics·E K Potter
Jun 24, 1982·Brain Research·T HashiguchiB Libet

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Citations

Oct 29, 2011·Therapeutic Advances in Cardiovascular Disease·Danielle IanzerRobson Augusto Souza Santos
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Sandrine N HardouinNeil M Nathanson
Mar 1, 2010·Current Protocols in Pharmacology·Scott ArmstrongSharath S Hegde

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