PMID: 2510210Jan 1, 1989Paper

Pressor, norepinephrine, and pituitary responses to two TRH doses in Alzheimer's disease and normal older men

Psychoneuroendocrinology
T H LampeM Raskind

Abstract

Changes in blood pressure (BP), plasma norepinephrine (NE), serum prolactin (PRL), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) associated with infusions of two thyrotropin-releasing hormone (TRH) doses (0.1 mg, 0.5 mg) were examined in 10 men with early-onset Alzheimer's disease (AD) and nine normal matched controls. During the first 5 min after TRH infusion, significant increases from baseline in systolic BP (p less than 0.001), diastolic BP (p less than 0.001), and plasma NE (p less than 0.006) occurred in the study subjects. The magnitude of the BP and NE responses did not differ significantly as a function of TRH dose (p greater than 0.3). Diastolic pressor responses to TRH were substantially blunted in AD subjects relative to controls, after both the 0.1-mg (p less than 0.003) and 0.5-mg (p less than 0.02) doses. There were trends toward attenuated responses in the AD subjects for systolic BP (p less than 0.09) and plasma NE (p less than 0.07). Significant increments in serum PRL, LH, and FSH (all p less than 0.001) also occurred after TRH, but the magnitude of the hormone responses did not differ significantly between the AD and the normal subjects (p greater than 0.18). These results suggest the poss...Continue Reading

References

Apr 10, 1986·The New England Journal of Medicine·R Katzman
May 1, 1986·Biological Psychiatry·C A PeabodyJ R Tinklenberg
Aug 1, 1986·Biological Psychiatry·P A NewhouseR M Cohen
Apr 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B KennedyJ C Gillin
Aug 1, 1987·Acta Psychiatrica Scandinavica·D R ThomasR John
Jan 1, 1988·Psychoneuroendocrinology·T H LampeM A Raskind
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·L S JacobsW H Daughaday
May 1, 1983·Archives of General Psychiatry·A WinokurD J Brunswick
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·G D BorowskiR A Levy
Jun 1, 1984·Archives of Internal Medicine·G P ZalogaC R Lake
Apr 1, 1984·Archives of General Psychiatry·M A RaskindD C Jimerson
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·R C VeithJ B Halter
Jan 1, 1981·Hormone Research·J E MorleyJ M Hershman
Jan 1, 1982·Psychoneuroendocrinology·P T LoosenA J Prange
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·H E Brezenoff, R Giuliano

❮ Previous
Next ❯

Citations

Oct 1, 1993·Biological Psychiatry·B VitielloT Sunderland
Jan 1, 1995·Acta Neurologica Scandinavica·A AlgotssonG Solders
Dec 18, 2013·Journal of the American Geriatrics Society·Rebecca H AffooRuth E Martin
Oct 8, 2020·Frontiers in Aging Neuroscience·Xiongfeng PanAizhong Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.