Pressor response to CSF sodium in mice: mediation by a ouabain-like substance and renin-angiotensin system in the brain

Brain Research
James W Van Huysse, Xiaohong Hou

Abstract

Intracerebroventricular (i.c.v.) infusion of sodium in rats increases cerebrospinal fluid (CSF) [Na], mimicking the effects of a high salt diet in salt-sensitive strains and causing sympathetic hyperactivity and a pressor response that are mediated via both an endogenous brain ouabainlike substance (OLS) and the brain renin-angiotensin system (RAS). However, the concept that CSF sodium activates both the brain OLS and brain RAS to increase blood pressure has not been tested in any other species besides the rat. In the current study, it was established that continuous i.c.v. infusion of NaCl causes sustained increases in blood pressure and heart rate in both outbred (Swiss Webster, SW) and inbred (C57Bl/6) mouse strains. Subsequently, the mechanisms of the pressor effects were explored. In both SW and C57Bl/6, the i.c.v. administration of Fab fragments of an antibody with high affinity for ouabain and the OLS (Fab) abolished the pressor and tachycardic responses to i.c.v. sodium, as did the angiotensin II AT1 receptor antagonist losartan given i.c.v. In contrast, doses of NaCl, Fab and losartan that were effective i.c.v. were ineffective when given i.v. I.c.v. ouabain also caused the pressor and tachycardic responses, which were...Continue Reading

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Citations

Nov 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mordecai P BlausteinW Gil Wier
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·James W Van HuysseHengwei Wu
Feb 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaohong HouJames W Van Huysse
Jul 10, 2012·Journal of Applied Physiology·Alexander Gabor, Frans H H Leenen
Mar 9, 2010·Cerebrospinal Fluid Research·Michael G HarringtonNathan F Dalleska
Apr 20, 2014·American Journal of Hypertension·Frans H H Leenen
Nov 6, 2007·Pathophysiology : the Official Journal of the International Society for Pathophysiology·James W Van Huysse
Mar 17, 2010·Biochimica Et Biophysica Acta·Frans H H Leenen
May 12, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Khristofor AgassandianMartin D Cassell
Feb 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Iva Dostanic-LarsonJerry B Lingrel
Aug 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sergei N Orlov, Alexander A Mongin

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