Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor

Biology of Sex Differences
Katrina M MirabitoKate M Denton

Abstract

The pressor response to angiotensin II (AngII) is attenuated in adult females as compared to males via an angiotensin type 2 receptor (AT2R)-dependent pathway. We hypothesized that adult female mice are protected against AngII-induced hypertension via an enhanced AT2R-mediated pathway and that in reproductively senescent females this pathway is no longer operative. Mean arterial pressure was measured via telemetry in 4-month-old (adult) and 16-month-old (aged) and aged ovariectomized (aged-OVX) wild-type and AT2R knockout (AT2R-KO) female mice during baseline and 14-day infusion of vehicle (saline) or AngII (600 ng/kg/min s.c.). Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to determine renal gene expression of angiotensin receptors and angiotensin-converting enzyme 2 in response to 14-day treatment with vehicle or AngII. Basal mean arterial pressure was similar between the groups. The pressor response to AngII was augmented in adult AT2R-KO compared to adult wild-type mice (29 ± 3 mmHg versus 10 ± 4 mmHg, respectively, on day 14 as compared to basal mean arterial pressure, P = 0.002). In wild-type mice, pressor responsiveness to AngII was augmented with age, such that the pressor response to AngII...Continue Reading

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Citations

Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sameed AhmedAnita T Layton
Apr 30, 2016·Clinical Science·Katrina M Mirabito ColafellaKate M Denton
Jun 3, 2016·British Journal of Pharmacology·C S SamuelR G Bennett
Nov 5, 2017·Clinical Science·Katrina M Mirabito ColafellaKate M Denton
Sep 18, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Jane BlackKate M Denton
May 31, 2018·American Journal of Physiology. Renal Physiology·Qianyi LiAnita T Layton
Oct 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dennis P PollowHeddwen L Brooks
Nov 30, 2016·Biology of Sex Differences·Giannie BarshaKatrina M Mirabito Colafella
Jun 10, 2015·Hypertension·Kate M Denton
Nov 26, 2018·Computers in Biology and Medicine·Jessica Leete, Anita T Layton
Feb 2, 2021·American Journal of Physiology. Renal Physiology·Ravi NistalaShawn B Bender
May 22, 2021·Hormones and Behavior·Jessica SantolloKatherine E Myers

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