Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough.

Respiratory Medicine
Yiqing ZhuZhong-Min Qiu

Abstract

Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC). The purpose of the study is to identify its therapeutic predictors in a prospective clinical study. 138 patients with suspected refractory GERC were treated with baclofen. Before the therapy, all the patients underwent esophageal manometry and multichannel intraluminal impedance-pH monitoring to establish the diagnosis. After the efficacy of baclofen was evaluated, a stepwise logistic regression analysis was performed to identify the therapeutic predictors of baclofen and to establish a regression prediction model. The overall response rate of baclofen treatment was 52.2% (72/138). The lower esophageal sphincter pressure (LESP) (odds ratio (OR) = 0.592, P = 0.000) and lower esophageal sphincter length (LESL) (OR = 0.144, P = 0.008) were independent predictors of baclofen efficacy. The optimal cut-off point to predict baclofen efficacy for LESP was 11.00 mmHg, with a sensitivity of 83.7% and specificity of 79.1% while that for LESL was 2.35 cm, with a sensitivity of 81.6% and specificity of 72.1%. The highest predictive specificity (90.7%) was achieved when both LESP and LESL were jointly used. LESP...Continue Reading

References

Sep 11, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M FeinC G Bremner
Mar 24, 2009·Pharmacology & Therapeutics·Anders Lehmann
Mar 10, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M A Kwiatek, P J Kahrilas
Oct 3, 2012·Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation·Kazuto TsuboiSumeet K Mittal
Jul 26, 2013·World Journal of Gastroenterology : WJG·Xiang-Huai XuZhong-Min Qiu
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mentore RibolsiMichele Cicala
Sep 29, 2015·World Journal of Methodology·Han-Jing Lv, Zhong-Min Qiu
Nov 7, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E ScarpelliniJ Tack
Sep 11, 2016·Chest·Peter J KahrilasUNKNOWN CHEST Expert Cough Panel
Feb 14, 2018·Gut·C Prakash GyawaliSabine Roman
Sep 14, 2019·The European Respiratory Journal·Alyn H MoriceAngela Zacharasiewicz
Sep 29, 2019·Journal of Thoracic Disease·Hongmei DingLi Yu
Oct 1, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jui-Sheng HungChien-Lin Chen
Mar 10, 2020·Gastrointestinal Endoscopy Clinics of North America·Robin A ZachariahRobert H Lee

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