Pressure dependency of aortic pulse wave velocity in vivo is not affected by vasoactive substances that alter aortic wall tension ex vivo

American Journal of Physiology. Heart and Circulatory Physiology
Mark ButlinAlberto P Avolio

Abstract

Aortic stiffness, a predictive parameter in cardiovascular medicine, is blood pressure dependent and experimentally requires isobaric measurement for meaningful comparison. Vasoactive drug administration to change peripheral resistance and blood pressure allows such isobaric comparison but may alter large conduit artery wall tension, directly changing aortic stiffness. This study quantifies effects of sodium nitroprusside (SNP, vasodilator) and phenylephrine (PE, vasoconstrictor) on aortic stiffness measured by aortic pulse wave velocity (aPWV) assessed by invasive pressure catheterization in anaesthetized Sprague-Dawley rats (n = 7). This was compared with nondrug-dependent alteration of blood pressure through reduced venous return induced by partial vena cava occlusion. In vivo drug concentration was estimated by modeling clearance rates. Ex vivo responses of excised thoracic and abdominal aortic rings to drugs was measured using myography. SNP administration did not alter aPWV compared with venous occlusion (P = 0.21-0.87). There was a 5% difference in aPWV with PE administration compared with venous occlusion (P < 0.05). The estimated in vivo maximum concentration of PE (7.0 ± 1.8 ×10(-7) M) and SNP (4.2 ± 0.6 ×10(-7) M) ca...Continue Reading

References

Dec 1, 1969·The American Journal of Physiology·P B Dobrin, A A Rovick
Jul 1, 1983·Psychophysiology·J R Jennings, S Choi
Jan 1, 1997·Journal of Applied Physiology·G F MitchellJ M Pfeffer
Jul 1, 1997·The American Journal of Physiology·C J HartleyM L Entman
Jul 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·P BoutouyrieS Laurent
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Feb 8, 2006·Circulation·Francesco U S Mattace-RasoJacqueline C M Witteman
Apr 12, 2011·American Journal of Physiology. Renal Physiology·Keith NgAlberto P Avolio
Aug 26, 2011·American Journal of Physiology. Renal Physiology·Keith NgJacqueline K Phillips
May 29, 2012·Cardiovascular Diabetology·Erik SalumJaak Kals
Apr 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Orestis VardoulisNikolaos Stergiopulos
Jul 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Sung Mee JungLakshmi Santhanam
Apr 12, 2014·Journal of the American Heart Association·Jochen SteppanLakshmi Santhanam

❮ Previous
Next ❯

Citations

Feb 21, 2016·Journal of the American Heart Association·Kaisa M Mäki-PetäjäIan B Wilkinson
Apr 10, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark ButlinAlberto P Avolio
Apr 1, 2017·Frontiers in Physiology·Sofie De MoudtPaul Fransen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved