Pressure-driven laminar flow in tangential microchannels: an elastomeric microfluidic switch

Analytical Chemistry
R F IsmagilovG M Whitesides

Abstract

This paper describes laminar fluid flow through a three-dimensional elastomeric microstructure formed by two microfluidic channels, fabricated in layers that contact one another face-to-face (typically at a 90 degree angle), with the fluid flows in tangential contact. There are two ways to control fluid flow through these tangentially connected microchannels. First, the flow profiles through the crossings are sensitive to the aspect ratio of the channels; the flow can be controlled by applying external pressure and changing this aspect ratio. Second, the flow direction of an individual laminar stream in multiphase laminar flow depends on the lateral position of the stream within the channel; this position can be controlled by injecting additional streams of fluid into the channel. We describe two microfluidic switches based on these two ways for controlling fluid flow through tangential microchannels and present theoretical arguments that explain the observed dependence of the flow profiles on the aspect ratio of the channels.

References

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Citations

Nov 2, 2013·Trends in Biotechnology·Gabor Jarvas, Andras Guttman
Jan 26, 2011·Biomicrofluidics·Siew-Kit HoiAndrew A Bettiol
Mar 28, 2007·Analytica Chimica Acta·Guiseng ZhangShigeru Terabe
Jun 8, 2006·Applied Spectroscopy·Khalil Abbas GhalebJoseph Georges
Mar 25, 2005·BioTechniques·Gina S Fiorini, Daniel T Chiu
Nov 22, 2007·Lab on a Chip·Cheuk-Wing Li, Mengsu Yang
Sep 8, 2010·Nanoscale·Heather K Hunt, Andrea M Armani
Apr 30, 2013·Chemical Society Reviews·Adam F ChrimesKourosh Kalantar-Zadeh
Jul 13, 2013·Lab on a Chip·Rachel R CollinoMatthew R Begley
Aug 21, 2014·Lab on a Chip·Cheuk-Wing LiMengsu Yang
Jan 22, 2009·Lab on a Chip·Seung Hwan LeeTai Hyun Park
Jul 23, 2004·Lab on a Chip·Christopher NeilsAlbert Folch
May 13, 2021·Annual Review of Analytical Chemistry·Nan ShiChristopher J Easley
Aug 11, 2021·Polymers·Nicolas ChenPreston B Moore
Jan 27, 2012·Analytical Chemistry·Valerie H LieuDaniel T Schwartz
Feb 6, 2013·The Journal of Physical Chemistry. B·Ziguang ChenLi Tan
Feb 2, 2011·Analytical Chemistry·Minh-Phuong Ngoc BuiGi Hun Seong
Aug 11, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·W Shannon DillmoreMilan Mrksich

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