PMID: 1211468Sep 1, 1975Paper

Pressure-flow and volume-flow relationships of the systemic circulation of the dog

The American Journal of Physiology
J F Green

Abstract

Mean systemic pressure-flow (Ps-Q) and volume-flow (V-Q) relationships of the systemic vascular bed were determined in two groups of dogs anesthetized with sodium pentobarbital (group I) and with methoxyflurane (group II). All blood returning to the heart (Q) was removed from the right atrial appendage and passed through a Starling resistor, a pump, a flowmeter , and then returned directly into the pulmonary artery. Ps was estimated from plateau values of right atrial pressure obtained during stop-flow procedures. Both the Ps-Q and V-Q relationships were nonlinear. This nonlinearity may be attributed to a redistribution of blood flow between systemic vascular compartments of unequal time constants. With group II, the Ps-Q and V-Q curves were shifted markedly to the right along the Ps and V axes, respectively. Evidence is presented which suggests that this shift was due to an effective back pressure other than right atrial pressure produced by a hepatic waterfall. The beta-adrenergic antagonist practolol increased the effective back pressure and augmented the shift in the Ps-Q and V-Q curves.

Citations

Apr 1, 1987·Acta Physiologica Scandinavica·O A Vengen, A Ilebekk
Jun 1, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan P Mynard, Joseph J Smolich
Jan 1, 1991·The American Review of Respiratory Disease·H E FesslerS Permutt
Feb 1, 1981·Circulation Research·J M Downey
Mar 10, 2000·Journal of Applied Physiology·H JellinekR D Fitzgerald
Mar 1, 1982·Hypertension·Y J Pan, D B Young
Dec 1, 1977·Annals of Biomedical Engineering·A P Jackman, J F Green
Feb 20, 2010·Current Opinion in Critical Care·Jos R C JansenMichael R Pinsky
Mar 1, 2019·Journal of Applied Physiology·Per Werner-MollerDavid Berger
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W Paulsen, G B Klintmalm
Aug 9, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J D SchipkeJ Winter
Dec 1, 1995·Journal of Critical Care·J A RomandR T Stanko

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