Pressure-induced gastric accommodation studied with a new distension paradigm. Abnormally low accommodation rate in patients with functional dyspepsia

Scandinavian Journal of Gastroenterology
Johan A LundingArnold Berstad

Abstract

A new distension paradigm, by which the gastric volume response to ramp-tonic distension can be analysed in detail, has been developed. The aim of this study was to investigate the applicability of this new paradigm in man, and to compare pressure-induced gastric accommodation in healthy volunteers (HV) and patients with functional dyspepsia (FD). Ten HV, and 11 FD patients were examined twice; once in the fasting state and once postprandially. Intragastric bag pressure was raised from 1 to 12 mmHg in 4 min (ramp phase) and then kept constant for 5 min (tonic phase). Compared to HV, fasting FD patients had lower gastric accommodation rates (0.9+/-0.2 versus 2.5+/-0.4 ml/s, p=0.002), lower maximum volume (239+/-39 versus 428+/-64 ml, p=0.01) and a longer accommodation time (157+/-26 versus 92+/-15 s, p=0.03). A test meal prior to distension tended to normalize the response in FD patients. This new barostat paradigm allowed detailed analysis of short-term pressure-induced accommodation in man. Impaired gastric distension-induced accommodation is a novel abnormality in FD.

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Citations

Jul 3, 2008·Digestive Diseases and Sciences·Masaki SanakaYasushi Kuyama
Feb 18, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SchirraB Göke
May 19, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J A LundingA Berstad
Feb 6, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J A LundingT Hausken
Nov 16, 2013·Surgical Neurology International·David R HansberryIra M Goldstein
May 24, 2006·World Journal of Gastroenterology : WJG·Odd Helge GiljaHans Gregersen
Oct 22, 2008·Scandinavian Journal of Gastroenterology·Pieter JanssenLeif Hultin
Oct 23, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pieter Vanden BergheJan Tack

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