Pressure-induced myogenic responses in human isolated cerebral resistance arteries

Stroke; a Journal of Cerebral Circulation
S J WallisW R Dunn

Abstract

Pressure-induced myogenic responses have been demonstrated in cerebral resistance arteries isolated from a number of species. In the present study, we determined the response of human isolated cerebral resistance arteries to a pressure stimulus. Arteries were set up in a pressure myograph and exposed to alterations in intravascular pressure. Human isolated cerebral resistance arteries developed spontaneous intrinsic tone in response to a pressure stimulus over the pressure range of 20 to 90 mm Hg that was not apparent in the absence of extracellular calcium. This intrinsic tone may be an inherent property of the vascular smooth muscle, since it remained after functional removal of the endothelium. Human isolated cerebral resistance arteries spontaneously contract when exposed to raised intravascular pressure. This pressure-induced myogenic response may contribute to cerebral autoregulation of blood flow.

References

Sep 1, 1992·The American Journal of Physiology·G A Meininger, M J Davis
Nov 1, 1985·The American Journal of Physiology·G Osol, W Halpern
Jun 1, 1994·Hypertension·G D'Angelo, G A Meininger
May 28, 1902·The Journal of Physiology·W M Bayliss

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Citations

Sep 11, 2012·Pflügers Archiv : European journal of physiology·Alexandra MardimaeJames Duffin
Apr 12, 2013·Current Hypertension Reports·Kaivan KhavandiAnthony M Heagerty
Nov 10, 1998·European Journal of Pharmacology·E LamI Laher
Jul 23, 1999·Survey of Ophthalmology·S OrgülJ Flammer
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Nov 1, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Erhard W LangNicholas W Dorsch
Mar 5, 2003·Journal of Neurotrauma·Erhard W LangNicholas W C Dorsch
Nov 26, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kaivan KhavandiAnthony M Heagerty
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M IngyinnM Viswanathan
Jun 2, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ma IngyinnBillie L Short
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·E W LangN W C Dorsch
Jun 29, 2012·Journal of Vascular Research·Akos Koller, Peter Toth
May 1, 2012·Clinical Imaging·Sema YildizOzlem Turksoy
Feb 26, 1999·The American Journal of the Medical Sciences·P A LowG W Petty
May 26, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter TothAkos Koller
Sep 24, 2004·Vascular Pharmacology·Ni BaiIsmail Laher
May 23, 2014·Purinergic Signalling·Claire M NicholsMaksym I Harhun
Dec 8, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Delia Cabrera DeBucAkos Koller
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Virginie BolducEric Thorin
Mar 24, 2016·AJR. American Journal of Roentgenology·Daniel S ChowJack Grinband
Mar 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shaoxun WangFan Fan
Mar 27, 2021·Physiological Reviews·Jurgen A H R ClaassenFrank M Faraci
Aug 10, 2021·Frontiers in Neurology·Darcy LidingtonSteffen-Sebastian Bolz

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